產(chǎn)品名稱(chēng)：human gene knockout HEK293 cell line
產(chǎn)品規(guī)格：10E6cell/管，2管
產(chǎn)品運(yùn)輸條件：干冰
產(chǎn)品儲(chǔ)存條件和期限：液氮，長(zhǎng)期保存
產(chǎn)品優(yōu)勢(shì)：
? 敲除有保障，無(wú)效退單或重新生產(chǎn)；
產(chǎn)品驗(yàn)收說(shuō)明：
收到細(xì)胞株包裹時(shí)，請(qǐng)立即檢查細(xì)胞株冷凍管是否有解凍情形，若有請(qǐng)立即拍照并通知公司。細(xì)胞株收到后請(qǐng)盡快開(kāi)展實(shí)驗(yàn)，如果想長(zhǎng)期保存請(qǐng)轉(zhuǎn)移至液氮中。
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
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