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● Autophagy.（IF=13.391）.Ruolin Li, et.al.（2021）. Piperine promotes autophagy flux by P2RX4 activation in SNCA/α-synuclein-induced Parkinson disease model.［首都醫(yī)科大學(xué) SNCA過表達(dá)質(zhì)粒 自噬、帕金森?。?

● NATURE COMMUNICATIONS.（IF=17.694）. Xiaolong Tang, et.al.（2021）. Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis .［浙江大學(xué) FLAG-AMPKα1 & FLAG-SKP2 & FLAG-AKT1過表達(dá)質(zhì)粒 惡性腫瘤］

● NATURE COMMUNICATIONS.（IF=17.694）. Lijuan Zhang，et.al.（2021）. Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage Polarization .［天津醫(yī)科大學(xué)Myc-IkBa & HA-UB K48 巨噬細(xì)胞］

● J Immunother Cancer.（IF=12.469）. Rui Qin，et.al.（2021）. Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation ［復(fù)旦大學(xué) NFATc過表達(dá)質(zhì)粒 色氨酸免疫激活］

● Genome Biology.（IF=17.906）. Xujia Wu，et.al.（2021）.A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity［中山大學(xué)第一附屬醫(yī)院 PTCH1 & Gli1過表達(dá)質(zhì)粒 膠質(zhì)母細(xì)胞瘤］

●  Neuro-Oncology. （IF=13.029）. Kaikai Yi，et.al.（2021）.PTRF/cavin-1 remodels phospholipid metabolism to promote tumor proliferation and suppress immune responses in glioblastoma by stabilizing cPLA2 . [天津醫(yī)科大學(xué) PTRF過表達(dá)質(zhì)粒 膠質(zhì)母細(xì)胞瘤]

●  EMBO Molecular Medicine.（IF=14.260）. Xujia Wu，et.al.（2021）.Nanog maintains stemness of Lkb1-deficient lung adenocarcinoma and prevents gastric differentiation. [中國科學(xué)院NANOG過表達(dá)質(zhì)粒 肺癌]

●  Cell Death & Disease.(IF=6.304) .Hao et al. (2020) .Dual regulation of p53 by the ribosome maturation factor SBDS. ［復(fù)旦大學(xué) SBDS過表達(dá)質(zhì)粒 肺癌和結(jié)腸癌］

●  Cell Death & Disease.(IF=6.304) .Fu et al. (2020) .Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression. ［香港浸會(huì)大學(xué) TLR4過表達(dá)質(zhì)粒 黑色素瘤］

●  Biochemical Pharmacology.(IF=4.96) .Li et al. (2020) .Downregulation of OCTN2 by Cytokines Plays an Important Role in the Progression of Inflammatory Bowel Disease. ［浙江大學(xué) SLC22A5過表達(dá)質(zhì)粒 HT29&FHC cells 炎癥性腸病IBD］

●  Cancer Letters.(IF=7.36) .Liu et al. (2020) .MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma. ［中南大學(xué)湘雅醫(yī)院 MYH9過表達(dá)質(zhì)粒 肺癌細(xì)胞］

●  Cancer Letters.(IF=7.36) .Luo et al. (2019) .DMBX1 promotes tumor proliferation and regulates cell cycle progression via repressing OTX2-mediated transcription of p21 in lung adenocarcinoma cell. ［江蘇省腫瘤醫(yī)院 肺癌細(xì)胞］

●  Redox Biology.(IF=9.986) .Tian et al. (2019) .aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院 PRKCI & KEAP1表達(dá)質(zhì)粒 膽囊癌］

●  Phytomedicine. (IF 7.9). Pan et.al. (2023). Synergistic neuroprotective effects of two natural medicinal plants against CORT-induced nerve cell injury by correcting neurotransmitter deficits and inflammation imbalance. [山東中醫(yī)藥大學(xué)中醫(yī)學(xué)院 miRNA-144-3p過表達(dá)和干擾質(zhì)粒 神經(jīng)]

●  Pharmacological Research.(IF=5.893) .Huang et al. (2020) .MiR-377-3p suppresses colorectal cancer through negative regulation on Wnt/β-catenin signaling by targeting XIAP and ZEB2.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院 mir377過表達(dá)質(zhì)粒 結(jié)直腸癌］

●  PPAR Research.(IF=2.953) .Xu et al. (2019) .Peroxisome Proliferator-Activated Receptor-γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p.［復(fù)旦大學(xué)附屬中山醫(yī)院 mir590過表達(dá)質(zhì)粒 內(nèi)皮損傷］

●  Theranostics.(IF=8.579) .Song et al. (2019) .Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院mir21過表達(dá)質(zhì)粒 急性心肌梗死MI］

●  Experimental Hematology & Oncology?(IF=9.4).Huang S, et.al. (2024). Combined inhibition of MET and VEGF enhances therapeutic efficacy of EGFR TKIs in EGFR-mutant non-small cell lung cancer  with concomitant aberrant MET activation.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院 熒光素酶報(bào)告基因質(zhì)粒構(gòu)建服務(wù)  EGFR突變型非小細(xì)胞肺癌］

●  Annals of the Rheumatic Diseases. (IF 27.4). Zhao et.al. (2023). SGLT2 inhibitors alleviated podocyte damage in lupus nephritis by decreasing inflammation and enhancing autophagy. [鄭州大學(xué)第一附屬醫(yī)院，sgRNA質(zhì)粒]

●  J Immunother Cancer.（IF=12.469）. Qi- Hua Peng，et.al.（2021）.CMTM6 and PD- L1 coexpression is associated with an active immune microenvironment and a favorable prognosis in colorectal cancer. ［中山大學(xué) pEnter- CMTM6- Flag過表達(dá)質(zhì)粒 直腸癌］

●  Cell Death Dis. (IF=6.304). Ma, et al. (2020). circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS.［江蘇省腫瘤醫(yī)院 pAV-circRNA 5615 結(jié)直腸癌］

●  Toxicol. Appl. Pharmacol. (IF=3.347). Ge & Tu, et al. (2020). MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1.［上海市第一人民醫(yī)院 & 上海交通上海交通大學(xué)醫(yī)學(xué)院 pcDNA3.1-FLAG-CCAR1 放射性直腸損傷］

●  Cell Death Dis. (IF=6.304). Zhang, et al. (2019). circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.［上海交通大學(xué)醫(yī)學(xué)院 pADM-circHIPK3-GFP 肺纖維化］

●  Int J Med Sci. (IF=2.523). Wang, et al. (2019). LncRNA SNHG6 promotes proliferation, invasion and migration in colorectal cancer cells by activating TGF-β/Smad signaling pathway via targeting UPF1 and inducing EMT via regulation of ZEB1.［南方醫(yī)科大學(xué) pCMV-SNHG6 結(jié)直腸癌］

●  EBioMedicine. (IF=5.736). Jiang, et al. (2019). Overexpression of PIMREG promotes breast cancer aggressiveness via constitutive activation of NF-κB signaling.［廣州醫(yī)科大學(xué) HA-tagged full-length p65 and the truncated p65 fragments plasmids 乳腺癌］

●  Aging (Albany NY). (IF=4.831). Li, et al. (2019). Sirt1-inducible deacetylation of p21 promotes cardiomyocyte proliferation.［南方醫(yī)科大學(xué)南方醫(yī)院 pcDNA3.1-FLAG-p21 WT & pcDNA3.1-FLAG-p21 KR & pcDNA3.1-FLAG-p21 KQ 心肌細(xì)胞增殖］

●  R Soc Open Sci. (IF=2.647). Liu, et al. (2018). Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS.［浙江大學(xué)醫(yī)學(xué)院附屬第一醫(yī)院pSH-U6-miR-143-5p-gRNA(or miR-143-3p-gRNA/miR-145-5p-gRNA/miR145-3p-gRNA)-CMV-SpCas9-P2A-Puro 人表皮角質(zhì)細(xì)胞HEKs 尖銳濕疣(CA)］

● International Journal of Oral Science（IF 14.9）.Zhang DX.（2024）. Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK.［山東大學(xué)，AdV5-CMV-GFP-LC3,AdV5-GFP-RFP-LC3，CAL 27細(xì)胞（人舌鱗癌細(xì)胞） MOI 100，口腔鱗狀細(xì)胞癌.］

● Biol Psychiatry. (IF=12.095). Zhao D, et al. (2019). RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits.［廈門大學(xué) Ad-PSD-95 & Ad-control GFP 阿爾茲海默癥］

● J Clin Endocrinol Metab. (IF=5.399). Li M, et al. (2019). The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.［山東大學(xué) Ad-HMGA2 多囊卵巢綜合征］

● Int J Cardiol. (IF=3.229). Wu B, et al. (2018). Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling.［湖北醫(yī)藥學(xué)院 Ad-Meox1 血管重塑］

● Life Sci. (IF=6.304). He M, et al. (2018). In vitro study of FUZ as a novel potential therapeutic target in non-small-cell lung cancer.［北京大學(xué) Ad-FUZ & Ad-NC 非小細(xì)胞肺癌］

● Cell Death Dis. (IF=6.304). Sun S, et al. (2017). Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院 Ad-PDK4 腫瘤代謝］

● Molecular Medicine Reports. (IF=2.1). Zhang S, et al. (2017). PAR1-mediated c-Jun activation promotes heat stress-induced early stage apoptosis of human umbilical vein endothelial cells. ［南方醫(yī)科大學(xué)南方醫(yī)院 Ad-PAR1 熱應(yīng)激誘導(dǎo)HUVEC凋亡］

● Hepatology. (IF=14.679). Xiang D, et al. (2017). Shp2 promotes liver cancer stem cell expansion by augmenting β-atenin signaling and predicts chemotherapeutic response of patients.［東方肝膽外科醫(yī)院 AdShp2 and AdGFP 肝癌］

● Cancer Letters. (IF=7.36). Wang Z , et al . (2017). CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrinβ1/FAK/AKT signaling.［中山大學(xué)附屬第一醫(yī)院 Ad-CXCL1胃癌］

● Gene. (IF=2.984). Zhang J W, et al. (2017). Validation of aspirin response-related transcripts in patients with coronary artery disease and preliminary investigation on CMTM5 function.［北京大學(xué)第一醫(yī)院 Ad-CMTM5-v1& Ad-mock 冠心?。?/a>

● Cell Death Dis. (IF=6.304). Zheng Y, et al. (2017). Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy. ［上海交通大學(xué)醫(yī)學(xué)院 & 中國科學(xué)院上海生命科學(xué)研究院 Ad-Atg5 缺血性心臟病］

● Oncoimmunology. (IF=5.869). Wang H, et al. (2016). Interactions between colon cancer cells and tumor-infiltrated macrophages depending on cancer cell-derived colony stimulating factor 1. ［山東齊魯醫(yī)院 Ad-hCSF1瘤內(nèi)注射 結(jié)腸癌］

● Basic Res Cardiol. (IF=11.981). Sun Z, et al. (2016). Cross-talk between macrophages and atrial myocytes in atrial fibrillation.［浙江大學(xué)醫(yī)學(xué)院附屬第一醫(yī)院 Ad-QKI 心房纖顫］

● Mol Carcinog. (IF=3.825). Wang J, et al. (2016). Endothelial cell-anchored tissue factor pathway inhibitor regulates tumor metastasis to the lung in mice.［復(fù)旦大學(xué) Ad-TFPI & Ad-GFP 腫瘤］

● Frontiers in Immunology. (IF 8.786). Huang et.al. (2023). FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K/NF-kB mediated endothelial oxidative stress. [華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院 Ad-FGL2-miRNA 血腦屏障]

● Hypertension. (IF=9.897).Junni Wang，et.al.（2021）.MicroRNA-87 4-3p/ADAM (A Disintegrin and Metalloprotease) 19 Mediates Macrophage Activation and Renal Fibrosis After Acute Kidney Injury. [浙江大學(xué)第一附屬醫(yī)院 Ad-miR-874-3p 腎纖維化]

● Stem Cells Int. (IF=3.869). Li X, et al. (2019). MicroRNA-150 Modulates Adipogenic Differentiation of Adipose-Derived Stem Cells by Targeting Notch3.［中國醫(yī)科大學(xué) Ad-miR-150 脂肪源性干細(xì)胞］

● Oncotarget. (IF=5.168). Tian S, et al. (2017). miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1.［貴州醫(yī)科大學(xué)附屬醫(yī)院 Ad-miR-138-5p & Ad-miR-NC 胰腺癌細(xì)胞自噬］

● Cell Communication and Signaling (IF=8.2). Ren X, et.al. (2025). REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling.［南京醫(yī)科大學(xué) Ad-Vec、Ad-REG3A、Ad-ΔREG3A  胰腺導(dǎo)管腺癌］

● Journal of Hazardous Materials (IF=12.2). Zhang Y, et.al. (2025). F-53B disrupts energy metabolism by inhibiting the V-ATPase-AMPK axis in neuronal cells.［石河子大學(xué)醫(yī)學(xué)院 Ad-V-ATPase B2  神經(jīng)毒性］

● Journal of Advanced Research（IF=11.4）. Sun K, et.al. (2024). TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院&武漢市第四醫(yī)院 Ad-TRPM2、Ad-GFP  骨關(guān)節(jié)炎］

● Cancer Immunology Research?(IF?8.1). Xiang X, et.al. (2024). Blocking CX3CR1+ Tumor-associated Macrophages Enhances the Efficacy of Anti-PD-1 Therapy in Hepatocellular Carcinoma.［杭州醫(yī)學(xué)院 Ad-CX3CR1、Ad-NC 肝細(xì)胞癌］

● Signal Transduction and Targeted Therapy (IF?40.8). Fang L, et.al. (2024). Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity.［北京大學(xué)/華南理工大學(xué)/西南醫(yī)科大學(xué)Ad-SMAD4、Ad-MYCBP2、Ad-NC 肥胖］

● Cell Death & Disease (IF 8.1). Peng et.al. (2024). Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α. [上海長征醫(yī)院謝渭芬、張鑫團(tuán)隊(duì) Ad-HNF1α(K197R)肝癌]

●Cell & Bioscience（IF 7.9）.Lei ZY.（2024）. Med1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation.［中山大學(xué)附屬第三醫(yī)院，Ad-CMV-Med1，尾靜脈注射,3.6×10^9 PFU,急性肝衰竭］

● Cell Communication and Signaling ( IF 8.2 ). Ma et.al. (2024). Low concentrations of saracatinib promote definitive endoderm differentiation through inhibition of FAK-YAP signaling axis. [西安交通大學(xué)第一附屬醫(yī)院丁小明團(tuán)隊(duì) 內(nèi)胚層分化]

● Redox Biology (IF 11.4). Shao et.al. (2024). FOXO1 regulates RUNX2 ubiquitination through SMURF2 in calcific aortic valve disease. [華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院董念國、李飛研究團(tuán)隊(duì)聯(lián)合南京醫(yī)科大學(xué)第一附屬醫(yī)院研究團(tuán)隊(duì) 鈣化性主動(dòng)脈瓣疾病]

● Molecular Metabolism (IF 8.1).Li J, et.al. (2024). Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3.［武漢大學(xué)人民醫(yī)院 Ad-DNER、Ad-DNER (Tyr⁶⁷⁷ to Ala)、Ad-HA 肝糖異生］

●Journal of Nanobiotechnology (IF 10.2).Ye L, et.al. (2024). Modulation of alveolar macrophage and mitochondrial fitness by medicinal plantderived nanovesicles to mitigate acute lung injury and viral pneumonia.［浙江樹人學(xué)院轉(zhuǎn)化醫(yī)學(xué)研究院 Ad-ACE2  急性肺損傷和病毒性肺炎］

●Nature Communications（IF 16.6）.Wang SJ.（2024）. Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity.［中山大學(xué)、廣州醫(yī)科大學(xué)附屬第一醫(yī)院，Ad5-GALNT3/T7，Ad5-EV，人肺腺癌細(xì)胞Calu-3，MOI 1000，新冠病毒防御機(jī)制］

●VIEW（IF 8.6）.Zhu JW.（2023）. The PES1/FOXM1 heterodimer suppresses TCF21 and ERβ expression in ovarian endometriosis.［北京大學(xué)第一醫(yī)院，Ad-Pes1，Ad-vector，體內(nèi)注射109pfu，子宮內(nèi)膜異位癥.］

●Acta Pharmaceutica Sinica B (IF 14.5). Rong et.al. (2024). Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis. [華西醫(yī)院杜丹、夏慶團(tuán)隊(duì)，Ad- XDH，胰腺炎]

●Cell Metabolism（IF 29）.Dong YM.（2024）. A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.［華中科技大學(xué)附屬同濟(jì)醫(yī)院，Ad-shRNA-Slc40a1（pAd-4 in 1 shRNA），骨髓源性巨噬細(xì)胞 MOI 200.骨質(zhì)疏松］

● Advanced Science（IF 15.1）.Ding L.（2024）. Beta-Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5.［山東大學(xué)基礎(chǔ)醫(yī)學(xué)院，Ad-CMV-Gnas，Ad-CMV-Tipe1，MIN6細(xì)胞/Islets細(xì)胞，2型糖尿病.］

●Journal of Medical Virology (IF 12.7). Yu et.al. (2023). SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species. [華中科技大學(xué)同濟(jì)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院，Ad5-S2NP]

●BMC Biology（IF 5.4）.You WJ.（2023）. GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1.［浙江大學(xué)，Ad-Gadd45a，Ad-Ctrl.小鼠/豬皮下脂肪細(xì)胞.脂肪代謝］

●J Clin Invest，（IF 15.9）.Yang ZY.（2023）. Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress.［第四軍醫(yī)大學(xué)，Ad-CTCF、Ad-Ctrl，人臍靜脈內(nèi)皮細(xì)胞(HUVECs)，MOI 200，腫瘤血管］

●Metabolism，（IF 9.8）.Hu YT.（2023）. Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation.［北京大學(xué)醫(yī)學(xué)部基礎(chǔ)醫(yī)學(xué)院、北京大學(xué)人民醫(yī)院，AAV8-FPR1、AAV8-GFP，尾靜脈注射，肝脂肪代謝］

●Acta Pharmacologica Sinica（IF8.2）.Huang YM, et.al. (2023). Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation.［廣州醫(yī)科大學(xué) Ad-hPar3L、Ad-GFP  動(dòng)脈粥樣硬化性心血管疾病］

●Journal of Translational Medicine (IF=7.4).Xiong W, et.al. (2023). UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院 Ad-UCP1 、Ad-Ctrl  腎間質(zhì)纖維化］

●Free Radical Biology and Medicine. (IF 7.4). Zhang et.al. (2023). Frataxin inhibits the sensitivity of the myocardium to ferroptosis by regulating iron homeostasis. [第四軍醫(yī)大學(xué)基礎(chǔ)醫(yī)學(xué)院、第四軍醫(yī)大學(xué)西京醫(yī)院，AAV和腺病毒過表達(dá)載體AAV9-cTNT-frataxin，Ad-Frataxin 心臟]

●JACC-Basic to Translational Science，（IF 9.531）. Zhu ZY.（2023）. Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis.［浙江大學(xué)醫(yī)學(xué)院附屬第二醫(yī)院 Adv-shGDF-11，心肌細(xì)胞（CMs），MOI=200，心力衰竭］

●Journal of Molecular Medicine，（IF 5.606）. Shao SY.（2023）. Never in mitosis gene Arelated kinase6 deficiency deterioratesdiabetic cardiomyopathy via regulating heat shock protein 72.［鄭州大學(xué)第一附屬醫(yī)院Ad-NEK6，MOI=50，心肌細(xì)胞，糖尿病心肌?。?/a>

●Signal Transduction and Targeted Therapy（IF 39.3）.Chunsik Lee. et.al.（2023）. VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway［中山大學(xué)中山眼科中心，瑞典卡羅林斯卡研究院聯(lián)合復(fù)旦大學(xué)附屬眼耳鼻喉科醫(yī)院Ad-FGFR1 WT，Ad-FGFR1 Y463F, Ad-FGFR1 Y585F，Ad-FGFR1 Y653F人臍靜脈內(nèi)皮細(xì)胞-HUVECs，MOI=10，血管］

●iScience （IF 6.107）.Li YJ.（2023）.Phosphodiesterase type 10A inhibitor attenuates lung 1 fibrosis by targeting myofibroblast activation［浙江大學(xué)醫(yī)學(xué)院附屬邵逸夫醫(yī)院 pADM-PDE10A，人胚肺成纖維細(xì)胞（HFL-1），肺部纖維化］

●ISCIENCE. (IF 6.107). Guo et.al. (2023). Steroidogenic factor 1 protects mice from obesity-induced glucose intolerance via improving glucose-stimulated insulin secretion by beta cells. [中山大學(xué)附屬第一醫(yī)院 AAV和腺病毒過表達(dá)載體 胰腺]

●Journal of Translational Medicine. (IF=8.44). Zhang RN, et.al. (2023). The spatiotemporal matching pattern of Ezrin/Periaxin involved in myoblast differentiation and fusion and Charcot-Marie-Tooth disease-associated muscle atrophy.［湖北醫(yī)藥學(xué)院 Ad-NFATc1、Ad-NFATc2、Ad-shNFATc3、Ad-shNFATc4、Ad-Null 腓骨肌萎縮癥］

●J CELL COMMUN SIGNAL.（IF=5.908）.Liu X, et.al. (2023). Sam68 promotes osteogenic differentiation of aortic valvular interstitial cells by TNF?α/STAT3/autophagy axis.［武漢協(xié)和醫(yī)院 Ad-Sam68 鈣化主動(dòng)脈瓣疾?。?/a>

●Journal of Nutritional Biochemistry.（IF=6.117）Liu J, et.al. (2023). Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院公共衛(wèi)生學(xué)院 Ad-Frataxin 酒精性肝病］

●Acta Pharmacologica Sinica. (IF 7.169) Guo et.al. (2023). JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit. [山東第一醫(yī)科大學(xué) JMJD6 腺病毒過表達(dá)載體 心肌肥厚]

●Journal of Neuroinflammation. (IF 9.587) Qian Xia et.al. (2022). Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1. [華中科技大學(xué)同濟(jì)醫(yī)院 SIRT5腺病毒過表達(dá)和干擾載體 神經(jīng)炎癥]

●Ecotoxicology and Environmental Safety. (IF 7.129) Jingjing Zhang et.al. (2023). The inhibition of TRPML1 TFEB leads to lysosomal biogenesis disorder contributes to developmental fluoride neurotoxicity. [新疆石河子大學(xué) TFEB腺病毒過表達(dá)載體 氟神經(jīng)毒性]

●ARTERIOSCL THROM VAS（IF=10.514）.Shu Liu，et.al.（2022）.Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein ［中國醫(yī)學(xué)科學(xué)院阜外醫(yī) AdV-TPRG1-AS1和AdVMYH9 動(dòng)脈粥樣硬化］

●Journal of Cachexia, Sarcopenia and Muscle.（IF=12.063）.You W , et.al. (2022). Growth arrest and DNA damage-inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha.［浙江大學(xué)動(dòng)物科學(xué)學(xué)院 Ad-GADD45A 肌內(nèi)脂肪沉積］

● Free Radical Biology and Medicine. (IF 8.101). Liu Y, et.al. (2022). LRRK2 deficiency protects the heart against myocardial infarction injury in mice via the P53/HMGB1 pathway.［鄭州大學(xué)第一附屬醫(yī)院 Ad-LRRK2 & Ad-LRRK2 D1994A & Ad-NC 心肌梗死］

● Journal of Molecular and Cellular Cardiology.（IF=5.763）.Wang S, et.al. (2022). Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair.［中山大學(xué)中山醫(yī)學(xué)院&南方醫(yī)科大學(xué)珠江醫(yī)院 Ad-SIRT6 & Ad-GFP 血管鈣化］

● Molecular Neurobiology. (IF=5.682). Zhou B, et.al. (2022). FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.［南昌大學(xué)第一附屬醫(yī)院 Ad-FUS & Ad-FUS-K510Q  肌萎縮側(cè)索硬化癥］

● Cell and Bioscience. (IF=9.584). Mao M, et.al. (2022). SENP6 induces microglial polarization and neuroinflammation through de-SUMOylation of Annexin-A1 after cerebral ischaemia–reperfusion injury. ［華中科技大學(xué)附屬同濟(jì)醫(yī)院&鄭州大學(xué)附屬中心醫(yī)院 Ad-SENP6 & Ad-vector 腦中風(fēng)］

● Arterioscler Thromb Vasc Biol.（IF=10.514）. Ren X, et.al. (2022). Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein. ［中國醫(yī)學(xué)科學(xué)院阜外醫(yī)院 Ad-TPRG1-AS1 & Ad-MYH9 動(dòng)脈粥樣硬化性心血管］

● Pharmacol Res.(IF=10.334). Zhu S, et al. (2022). The miR-145-MMP1 axis is a critical regulator for imiquimod-induced cancer stemness and chemoresistance. ［吉林大學(xué)第一醫(yī)院轉(zhuǎn)化醫(yī)學(xué)研究所 Ad-miR-145 & Ad-control 腫瘤干性］

● Acta Biomaterialia.（IF=10.633）. Wang F, et.al. (2022). Adipose-derived stem cells with miR-150-5p inhibition laden in hydroxyapatite/tricalcium phosphate ceramic powders promote osteogenesis via regulating Notch3 and activating FAK/ERK and RhoA. ［中國醫(yī)科大學(xué) Ad-miR-150-5p & Ad-NC 骨質(zhì)疏松癥］

● Molecular Cancer. (IF=41.444).Lei Liu，et.al.（2021）.KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1. ［山東大學(xué)Ad-KDM6A & Ad-GFP 膀胱癌］

● Signal Transduction and Targeted Therapy.（IF=38.104）.Suowen Xu, et.al.（2021）.The zinc fifinger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction.［中國科技大學(xué) Ad-KLF2 & Ad-GFP 內(nèi)皮功能障礙］

● Redox Biology .(IF=10.787).Yaqian Huang，et.al.（2021）.Endogenous SO2-dependent Smad3 redox modification controls vascular remodeling. [北京大學(xué)第一醫(yī)院 Ad-AAT1 血管重塑]

● Theranostics.（IF=38.104）.Yan Jiang, et.al.（2021）. Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis. [復(fù)旦大學(xué)Ad-Jmjd3 & Ad-Jmjd3-mut肝纖維化]

● Nat Commun. (IF=17.694). Liu R, et.al. (2022). MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake. ［山東第一醫(yī)科大學(xué)附屬眼科研究所Ad-GFP＆Ad-CMV-Glut2＆Ad-insulin 1-miR-21  胰腺β細(xì)胞］

● Cell Metab. (IF=27.287). Zhou N, et.al. (2022). Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses. ［北京大學(xué)&山一大附屬省立醫(yī)院 Ad-PPARd &Ad-OTUD3&Ad-control 糖脂代謝］

● Genes & Diseases. (IF=7.103). Luo J, et.al. (2022). PLSCR1 Promotes Apoptosis and Clearance of Retinal Ganglion Cells in Glaucoma Pathogenesis. ［中山大學(xué)Ad-PLSCR1&Ad-control 青光眼］

●  J Cell Physiol.  (IF=5.546) . Wang M, et al. (2021) . Lack of Mof reduces acute liver injury by enhancingtranscriptional activation of Igf1. [過表達(dá)/干擾 急性肝損傷]

●  Front Cell Dev Biol.  (IF=5.201) . Gu J, et al. (2021) . CFTR Deficiency Affects Glucose Homeostasis via Regulating GLUT4 Plasma Membrane Transportation. [過表達(dá) 成肌細(xì)胞]

●  Front Immunol.  (IF=5.085) . Wu L, et al. (2021) . EZH2 Inhibition Interferes With the Activation of Type I Interferon Signaling Pathway and Ameliorates Lupus Nephritis in NZB/NZW F1 Mice. [過表達(dá) 狼瘡腎炎]

●  [4]Oxid Med Cell Longev.  (IF=5.076) . Gao Y, et al. (2021) .Rap1GAP Mediates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Inhibiting Autophagy and Increasing Oxidative Stress. [過表達(dá) 心肌]

●  J Cell Mol Med.  (IF=4.486) . Lei W，et al. (2021) . MARCH5 restores endothelial cell function against ischaemic/hypoxia injury via Akt/eNOS pathway. [過表達(dá) 心肌]

●  J Biol Chem.  (IF=4.238) . Zhang Z，et al. (2021) . The adaptor protein GIPC1 stabilizes the scavenger receptor SR-B1 and increases its cholesterol uptake. [過表達(dá)/干擾 肝臟]

●  J Anim Sci Biotechnol.  (IF=4.167) . Liu J, et al. (2021) . Comprehensive evaluation of the metabolic effects of porcine CRTC3 overexpression on subcutaneous adipocytes with metabolomic and transcriptomic analyses. [過表達(dá) 脂肪細(xì)胞]

●  Aging. (IF=4.831) .Chen Y, et al. (2020). Mitophagy impairment is involved in sevoflurane-induced cognitive dysfunction in aged rats[自噬雙標(biāo) 術(shù)后認(rèn)知功能障礙].

● Elife Tool. (IF=7.08). Wu L, et al. (2019). PARIS, an optogenetic method for functionally mapping gap junctions.［北京大學(xué) Ad-CMV-pHluorinCAAX 縫隙連接探針］

● Cell Death Dis. (IF=6.304). Su Y, et al. (2019). MicroRNA-181a-5p and microRNA-181a-3p cooperatively restrict vascular inflammation and atherosclerosis.［中山大學(xué)眼科中心 & 中山大學(xué)中山醫(yī)學(xué)院 Ad-TAB2 & Ad-NEMO HUVECs 動(dòng)脈粥樣硬化］

● EBioMedicine. (IF=5.736). Wang K, et al. (2019). TGF-beta1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM.［溫州醫(yī)科大學(xué)附屬臺州醫(yī)院 Ad-p65 & Ad-EV 肝纖維化］

● Arthritis Res Ther. (IF=4.103). Zeng J, et al. (2019). Interferon-alpha exacerbates neuropsychiatric phenotypes in lupus-prone mice.［上海交通大學(xué)醫(yī)學(xué)院附屬仁濟(jì)醫(yī)院 Adv-IFN-α & Adv-ctrl系統(tǒng)性紅斑狼瘡］

● Oncogene. (IF=7.971). Yu M, et al. (2018). Circadian regulator NR1D2 regulates glioblastoma cell proliferation and motility. ［北京大學(xué)深圳研究生院 Ad-AXL 膠質(zhì)母細(xì)胞瘤］

● Cell Death Discov. (IF=4.114). Zhang SQ, et al. (2018). Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3beta activity.［香港浸會(huì)大學(xué) Ad-GSK3β (S9A) 神經(jīng)干細(xì)胞NSCs］

● Int J Mol Med. (IF=3.098). Zhang L, et al. (2018). Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-kappaB pathway.［武漢大學(xué)人民醫(yī)院張杰團(tuán)隊(duì) Ad-Lefty-1 腎臟炎］

● Redox Biol. (IF=9.986). Jin Q, et al. (2018). DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways.［中國人民解放軍總醫(yī)院 Ad-DUSP1 & Ad-ctrl 心臟缺血再灌注損傷］

● Cell Physiol Biochem. (IF=5.5). Wang Y, et al. (2018). Inhibition of Histone Deacetylases Prevents Cardiac Remodeling After Myocardial Infarction by Restoring Autophagosome Processing in Cardiac Fibroblasts. ［浙江大學(xué)醫(yī)學(xué)院附屬第二醫(yī)院Ad- mCherry-GFP-LC3 心臟重塑］

● Brain,Behavior,and Immunity. (IF=6.633). Zhou Y.T, et al. (2017). Interleukin-1βimpedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion.［浙江大學(xué) Ad-IL-1R1-RFP & Ad-RFP 皮層下缺血性血管性癡呆SIVD］

● J Pharmacol Sci. (IF=2.835). Li J, et al. (2016). PKCζ interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy.［中山大學(xué) Ad-PKCζ & Ad-GFP心肌肥厚］

● Arthritis Rheumatol. (IF=9.586). Han X, et al. (2016). MicroRNA-130b Ameliorates Murine Lupus Nephritis Through Targeting the Type I Interferon Pathway on Renal Mesangial Cells.［上海交通大學(xué)醫(yī)學(xué)院 Ad-IFNα5 狼瘡腎炎］

● Sci Rep. (IF=3.998). Zhang H, et al. (2016). Endogenous sulfur dioxide is a novel adipocyte-derived inflammatory inhibitor. entific Reports.［北京大學(xué)第一醫(yī)院 Ad-AAT1 3T3-L1 cell 脂肪組織慢性炎癥］

● Mol Cell Biol. (IF=3.611). Wu C, et al. (2016). Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity.［南方科技大學(xué) Ad-Cre RNA聚合酶I轉(zhuǎn)錄活性］

● Cell Death Discovery (IF=6.1). Wei X, et.al. (2024). Tert promotes cardiac regenerative repair after MI through  alleviating ROS-induced DNA damage response in cardiomyocyte.［南方醫(yī)科大學(xué)南方醫(yī)院 ADV-shTert、ADV-sh-NC  心肌再生］

● Molecular Metabolism (IF 8.1).Li J, et.al. (2024). Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3.［武漢大學(xué)人民醫(yī)院 Ad-U6-shDNER、Ad-U6-shRNA control 肝糖異生］

● ACS Applied Materials & Interfaces（IF 9.5）.Yu KX.（2023）. Cancer-Erythrocyte Membrane-Mimicking Fe3O4 Nanoparticles and DHJS for Ferroptosis/ Immunotherapy Synergism in Tumors.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院、湖北科技學(xué)院、武漢大學(xué)中南醫(yī)院，Ad-shRNA-Nrf2，Ad-shRNA-con.HOS細(xì)胞（人骨肉瘤細(xì)胞）MOI 50.骨肉瘤］

● Pharmacol Res.（IF=10.334）. Dong Y, et.al. (2022). Blocking the cytohesin-2/ARF1 axis by SecinH3 ameliorates osteoclast-induced bone loss via attenuating JNK-mediated IRE1 endoribonuclease activity. ［華中科技大學(xué)附屬同濟(jì)醫(yī)院 Ad-4in1-shCytohesin-1 ；Ad-4in1-shCytohesin-2；Ad-4in1-shCytohesin-3；Ad-4in1-shNC 骨質(zhì)疏松］

● Mol Ther. (IF=12.910). Zheng H, et al. (2022) . CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output. ［南方醫(yī)科大學(xué) Ad-shcircSamd4 & Ad-NC 心肌梗死］

● Biomedicine & Pharmacotherapy.（IF=7.419）. Hong Q, et.al. (2022). Trimethylamine-N-oxide (TMAO) promotes balloon injury-induced neointimal hyperplasia via upregulating Beclin1 and impairing autophagic flux .［南方醫(yī)科大學(xué)珠江醫(yī)院 Ad-shBeclin1 & Ad-shNC 血管重塑］

● Journal of Cellular and Molecular Medicine. (IF=4.486). Wang, et al. (2020). Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss. ［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院同濟(jì)醫(yī)院骨科 murine PFKFB3 Adenoviruses-4 in 1 shRNA-GFP 骨髓源性巨噬細(xì)胞BMMs MOI=50 破骨細(xì)胞相關(guān)疾?。?/a>

● EBioMedicine. (IF=5.736. Li, et al. (2019). Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathway.［南方醫(yī)科大學(xué)南方醫(yī)院 AZIN2-sv Adenoviruses-4 in 1 shRNA-GFP 人臍靜脈內(nèi)皮細(xì)胞HUVECs MOI=100 新血管形成］

● Bone. (IF=4.147). Zhao, et al. (2018). YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院同濟(jì)醫(yī)院骨科 murine YAP1 Adenoviruses-4 in 1 shRNA-GFP 骨髓源性巨噬細(xì)胞BMMs & RAW264.7 cells 破骨細(xì)胞生成］

● Cardiovascular Research. (IF=8.168. Li, et al. (2018). Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration.［南方醫(yī)科大學(xué)南方醫(yī)院 AZIN2-sv Adenoviruses-4 in 1 shRNA-GFP 心肌細(xì)胞CMs MOI=100 & 大鼠心肌注射 心臟再生］

● Br J Pharmacol. (IF=6.304). Ma Z.G, et al. (2016). Protection against cardiac hypertrophy by geniposide involves the GLP-1 receptor / AMPKalpha signalling pathway. ［武漢大學(xué)人民醫(yī)院 Ad-shAMPKα2 心肌肥厚］

● Clin Sci . (IF=5.223). Ling Y, et al. (2016). Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux. ［南方醫(yī)科大學(xué)珠江醫(yī)院 Ad-sh-Beclin1&Ad-NC 心肌缺血再灌注損傷］

● Int J Biol Sci. (IF=4.858). Ma Z G, et al. (2016). Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKalpha Signalling Pathway. ［武漢大學(xué)人民醫(yī)院 Ad-shAMPKα2 心肌肥厚］

● Nat Commun. (IF=12.121). Fu R, et al. (2020). Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis. ［中國藥科大學(xué)Ad-βGal & Ad-Cre 骨質(zhì)疏松］

● Cancer Sci. (IF=4.966). Wang X, et al. (2020). Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo. ［南方科技大學(xué)Ad-LacZ & Ad-Cre 肺癌］

● Int. J. Mol. Sci. (IF=4.556). Xu, et al. (2020). Effective MSTN Gene Knockout by AdV-Delivered CRISPR/Cas9 in Postnatal Chick Leg Muscle.［上海交通大學(xué) AdV-CRISPR system(pAdM-U6-gRNA1-U6-gRNA2-CMV-spCas9) 雞胚成纖維細(xì)胞DF-1 MOI=1000 & 雞肌肉注射 雞骨骼肌的生長和發(fā)育］

● ACS Nano.（IF=18.027）.ChunHua-Zhao，et.al.（2023）.Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer.［中山大學(xué)腫瘤防治中心、東海大學(xué)LV-EF1a-luciferase-CMV-GFP-P2A-Puro三陰性乳腺癌］

● Nature Communications (IF 14.7). chen et.al. (2024). The lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression. [南方醫(yī)科大學(xué)李學(xué)農(nóng)團(tuán)隊(duì) 結(jié)直腸癌]

● Journal of Advanced Research（IF 11.4）.Huang XG.（2024）. Exploitation of enhanced prime editing for blocking aberrant angiogenesis.［深圳市眼科醫(yī)院 , NILV-LV5、NILV-LV6、NILVs-PE6x-VEGFR2、NILVs-PE6x-lacZ，視網(wǎng)膜血管生成］

● International Journal of Biological Sciences (IF 8.2).Lu F, et.al. (2024). Hypoxic tumor-derived exosomal miR-4488 induces macrophage M2 polarization to promote liver metastasis of pancreatic neuroendocrine neoplasm through RTN3/FABP5 mediated fatty acid oxidation.［南京醫(yī)科大學(xué)第一附屬醫(yī)院 miR-4488過表達(dá)及干擾慢病毒載體 胰腺神經(jīng)內(nèi)分泌腫瘤］

● Cancer Letters（IF 9.1）.Meng HY.（2024）. YBX1 promotes homologous recombination and resistance to platinum-induced stress in ovarian cancer by recognizing m5C modification.［南京醫(yī)科大學(xué)第一附屬醫(yī)院，LV-CMV-YBX1、LV-CMV-shYBX1，卵巢癌］

●Clin. Transl. Med.（IF 7.9）.Guan X.（2024）. Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer.［哈爾濱醫(yī)科大學(xué)附屬腫瘤醫(yī)院，PLent-Puro-CMV-NLRP3慢病毒載體，結(jié)直腸癌］

● Oncogene (IF 8.0). Wei et.al. (2024). The splicing factor WBP11 mediates MCM7 intron retention to promote the malignant progression of ovarian cancer. [山東大學(xué)齊魯醫(yī)院宋坤/李英偉團(tuán)隊(duì) 卵巢癌]

●Cell Death & Disease?(IF?9.0).Yao Y, et.al. (2024). Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes.［山東中醫(yī)藥大學(xué)附屬醫(yī)院 Lenti-PDK1 、Lenti-GFP 糖尿病神經(jīng)病變］

Cancer Immunology Research (IF 10.1). Wang et.al. (2023). Combination anti-PD-1 and electroacupuncture induces a potent anti-tumor immune response in microsatellite-stable colorectal cancer. [哈爾濱醫(yī)科大學(xué)鄭桐森團(tuán)隊(duì)，pLent-Puro-CMV–luciferase，結(jié)直腸癌]

● Journal of Experimental & Clinical Cancer Research (IF 11.3). Xie et.al. (2023). Gastric cancer-derived LBP promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation. [南京醫(yī)科大學(xué)附屬第一醫(yī)院，LV-LBP、LV-shLBP、LV-TLR4、LV-NC、LV-GFP，胃癌肝轉(zhuǎn)移]

● Cell Death & Bioactive Materials (IF 18.9). Wu et.al. (2024). Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair. [中南大學(xué)湘雅醫(yī)院、中國科學(xué)院遺傳與發(fā)育生物學(xué)研究所聯(lián)合北京藥理學(xué)與毒理學(xué)研究所，Lv-TrkC，脊髓損傷修復(fù)]

● Cellular and Molecular Life Sciences. (IF 8.0). Song et.al. (2023). FKBP5 deficiency attenuates calcium oxalate kidney stone formation by suppressing cell–crystal adhesion, apoptosis and macrophage M1 polarization via inhibition of NF-κB signaling. [武漢大學(xué)人民醫(yī)院、武漢大學(xué)技術(shù)科學(xué)研究所，AAV干擾載體、慢病毒過表達(dá)和干擾載體 腎臟]

● Cellular & Molecular Biology Letters，（IF 8.3）. Kuang Xiangqin.（2023）. Peptidase inhibitor (PI16) impairs bladder cancer metastasis by inhibiting NF-κB activation via disrupting multiple-site ubiquitination of NEMO.［廣州醫(yī)科大學(xué)附屬腫瘤醫(yī)院，Lv-PI16，Lv-shRNA-PI16，膀胱癌-BLCA細(xì)胞］

● Cell Death Discovery. (IF 7.0). Zhang et.al. (2023). Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis. [南京醫(yī)科大學(xué)第一附屬醫(yī)院 AAV慢病毒過表達(dá)載體 AAV9-RCAN1.4 LV-RCAN1.4、LV-YY1  腎臟]

● Death and Disease，（IF 9.685）. Xie XF.（2023）. BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids.［中國醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院，LV-BACH1、LV-shBACH1，食管鱗狀細(xì)胞癌］

● Cancer Immunology, Immunotherapy，（IF 6.63）. Wu PT.（2023）. LILRB2-containing small extracellular vesicles from glioblastoma promote tumor progression by promoting the formation and expansion of myeloidderived suppressor cells［蘇州大學(xué)第二附屬醫(yī)院&上海華山醫(yī)院LV-pirb & LV-pirb-RFP & LV-nc 小鼠膠質(zhì)母細(xì)胞瘤GL261細(xì)胞系 MOI=50， 膠質(zhì)母細(xì)胞瘤］

● The Journal of Nutritional Biochemistry.（IF=5.6）.Chen H, et.al. (2023). Autophagy and exosomes coordinately mediate quercetin's protective effects on alcoholic liver disease.［華中科技大學(xué) Lv-CYP2E1 酒精性肝?。?

● Journal of Translational Medicine（IF=8.440）Bo Sun，et.al.（2023）.AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway.［湖南省人民醫(yī)院 AFAP1L1/VAV2/ITGA5過表達(dá)以及干擾慢病毒 胃癌］

● Cell Death Discovery. (IF 7.0) Wang et.al. (2023). NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress. [湖北醫(yī)藥學(xué)院 NSUN2慢病毒過表達(dá)載體 心臟]

● Journal of Experimental & Clinical Cancer Research. (IF 12.658) Huang et.al. (2023). Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling. [中山大學(xué)孫逸仙紀(jì)念醫(yī)院 LCN2慢病毒過表達(dá)和敲除載體 口腔鱗狀細(xì)胞癌]

● Molecular Cell. (IF 19.328) Jinzhou Huang et.al. (2023). SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology. [同濟(jì)大學(xué)醫(yī)學(xué)院 53BP1慢病毒干擾過表達(dá)載體 DNA修復(fù)]

● CNS Neurosci Ther.（IF=7.035）. Miao Y，et.al. (2023). Anti-cancer effect of targeting fibroblast activation protein alpha in glioblastoma through remodeling macrophage phenotype and suppressing tumor progression.［首都醫(yī)科大學(xué)附屬北京天壇醫(yī)院 Lv-FAP 膠質(zhì)母細(xì)胞瘤］

●Oncogene.（IF=8.756）. Chen H，et.al. (2022). Extracellular vesicles-transferred SBSN drives glioma aggressiveness by activating NF-κB via ANXA1-dependent ubiquitination of NEMO.［廣州醫(yī)科大學(xué) Lv-SBSN 膠質(zhì)瘤］

●Cell Reports.（IF=9.995）. Li H, et.al. (2022). β-hydroxybutyrate reduces reinstatement of cocaine conditioned place preference through hippocampal CaMKII-a β-hydroxybutyrylation.［四川大學(xué)華西醫(yī)院 pLenti-EF1α-CMV-CaMKII-α-Flag-GFP-2A-Puro；pLenti-EF1α-CMV-mutant CaMKII-α-Flag-GFP-2A-Puro 藥物成癮］

● Cancer Letters.（IF=9.756）.Wang Y , et.al. (2022). NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity.［浙江大學(xué)醫(yī)學(xué)院 Lv-NNMT&Lv-NNMTY20 乳腺癌］

● J Exp Clin Cancer Res.（IF=12.658）. Qiu S, et.al. (2022). Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis.［南京醫(yī)科大學(xué)第一附屬醫(yī)院 Lv-miR-519a-3p ；Lv-miR-519a-3p-shRNA 胃癌肝轉(zhuǎn)移］

● Cancer Lett. (IF=9.756). Wang Y, et.al. (2022). NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity. ［浙江大學(xué)醫(yī)學(xué)院 pLenti-Pur-NNMT & pLenti-Pur-NNMT-Y20 & pLenti-Pur 乳腺癌］

● EBioMedicine. (IF=11.205). Xiao RW, et.al. (2022). Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication. ［中山大學(xué)附屬腫瘤醫(yī)院 Lv-POLN 鼻咽癌］

● J Exp Clin Cancer Res. (IF=12.658). Qiu S, et.al. (2022). Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis. ［南京第一附屬醫(yī)院 Lv-miR-519a-3p&Lv-miR-519a-3p-shRNA 胃癌］

● Am J Med Sci. (IF=3.462). Luo R. (2022). CircRNA circ-MYBL2 absorbs precursor miR-92b in the nucleus to suppress its role in enhancing gastric cancer cell proliferation. ［成都人民醫(yī)院 LV-circ-MYBL2 胃癌］

● Cancer Letters. (IF=9.756).Peng Nan, et.al.(2021).Tumor-stroma TGF-β1-THBS2 feedback circuit drives pancreatic ductal adenocarcinoma progression via integrin αvβ3/CD36-mediated activation of the MAPK pathway.［中國醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院Lv-shPCK2-1 & Lv-shPCK2-2胰腺導(dǎo)管腺癌］

● Cancer Letters. (IF=9.756). Xiaofeng Li，et.al.(2021).SETD8 stabilized by USP17 epigenetically activates SREBP1 pathway to drive lipogenesis and oncogenesis of ccRCC.［山東大學(xué)齊魯醫(yī)院pLent-U6- SETD8-GFP-Puro 腎細(xì)胞癌］

● J Immunother Cancer.（IF=12.469）. Chao Liu,et.al.(2021).Blocking IL- 17A enhances tumor response to anti- PD- 1 immunotherapy in microsatellite stable colorectal cancer [哈爾濱醫(yī)科大學(xué)腫瘤醫(yī)院pLent-Puro- CMV- miR-15b-5p & AAV- miR- 15b- 5p 直腸癌 ]

● Cell Death & Disease. (IF=6.304). Liu, et al. (2020). Long noncoding RNA SNHG12 promotes tumour progression and sunitinib resistance by upregulating CDCA3 in renal cell carcinoma.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院pLent-SNHG12-GFP-Puro & pLent-shSNHG12-GFP-Puro 腎癌細(xì)胞RCC cells］

● Cell Death & Disease. (IF=6.304). Liu, et al. (2020). Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression.［香港浸會(huì)大學(xué) lentivirus-CA-TLR4, fused with Myc and Flag tags 黑色素瘤細(xì)胞A375 cells］

● Cell Death & Disease. (IF=6.304). Wang, et al. (2019). LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院 pLent-LXRα-GFP-Puro & pLent-GFP-sh-LXRα-Puro 腎癌細(xì)胞RCC cells］

● Biochemical and Biophysical Research Communications. (IF=2.985). Zhu, et al. (2019). MicroRNA-506 inhibits the proliferation and invasion of mantle cell lymphoma cells by targeting B7H3.［北京大學(xué)第三醫(yī)院 lent-miR-506 套細(xì)胞淋巴瘤細(xì)胞］

● Molecular Cancer. (IF=15.302). Tan, et al. (2019). PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA.［中山大學(xué) pLent-Puro-GFP-piR-36712 人乳腺癌細(xì)胞MCF7和ZR75-1］

● Advanced Science. (IF=15.84). Lai, et al. (2018). A Modular Assembly of Spinal Cord–Like Tissue Allows T argeted Tissue Repair in the T ransected Spinal Cord. ［中山大學(xué) pLent-EF1a-NT-3-Flag-CMV-GFP-P2A-Puro & pLent-EF1a-TrkC-Flag-CMV-GFP-P2A-Puro & pLent-EF1a-CNTF-Flag-CMV-GFP-P2A-Puro 神經(jīng)干細(xì)胞NSCs & 少突膠質(zhì)前體細(xì)胞OPCs 脊髓損傷］

● Theranostics. (IF=8.579). Mai, et al. (2018). PIWI-interacting RNA-54265 is oncogenic and a potential therapeutic target in colorectal adenocarcinoma.［中山大學(xué) pLent-Puro-GFP-piR-54265 人結(jié)腸癌細(xì)胞HCT116和LoVo］

● Toxicology Letters. (IF= 3.569). Yan, et al. (2018). Inhibitory Effect of PXR on Ammonia-induced Hepatocyte Autophagy via P53.［福建醫(yī)科大學(xué)附屬協(xié)和醫(yī)院 pLent-EF1a-PXR-CMV-GFP & pLent-U6-shPXR-GFP-Puro 人肝細(xì)胞HL-7702 和人肝癌細(xì)胞 BEL-7404 肝自噬］

● Journal of Advanced Research (IF 11.4) Jia et.al. (2025). Comprehensive multi-omics analyses exposes a precision therapy strategy that targets replication stress in hepatocellular carcinoma using WEE1 inhibition. [浙江大學(xué)醫(yī)學(xué)院附屬第一醫(yī)院鄭樹森院士、宋朋紅 人源激酶gRNA慢病毒文庫 肝細(xì)胞癌]

● Journal of Advanced Research (IF 11.4) Xie et.al. (2024). Targeting ATM enhances radiation sensitivity of colorectal cancer by potentiating radiation-induced cell death and antitumor immunity. [南方醫(yī)科大學(xué)南方醫(yī)院丁軼、方媛、詹益芝團(tuán)隊(duì) Lv-shATM、Lv-shNC 結(jié)直腸癌]

● Free Radical Biology and Medicine (IF=7.1). Ji R, et.al. (2024). Platycodin D ameliorates polycystic ovary syndrome-induced ovarian damage by upregulating CD44 to attenuate ferroptosis.［武漢大學(xué)人民醫(yī)院 Lv-sh-CD44、Lv-sh-SLC7A11、Lv-sh-NC  多囊卵巢綜合征］

● Cell Communication and Signaling (IF 8.4).Li H, et.al. (2024). VDR promotes pancreatic cancer progression in vivo by activating CCL20-mediated M2 polarization of tumor associated macrophage.［哈爾濱醫(yī)科大學(xué)附屬腫瘤醫(yī)院 Lv-shVDR 胰腺癌］

● Cell Death and Differentiation (IF 12.4).Du Y, et.al. (2024). APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy. ［南京師范大學(xué) Lv-shAPE1 肝細(xì)胞癌］

● Pharmacological Research (IF 9.3). Peng et.al. (2024). Gut Clostridium sporogenes-derived indole propionic acid suppresses osteoclast formation by activating pregnane X receptor. [華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院李鋒、關(guān)邯峰團(tuán)隊(duì)聯(lián)合重慶大學(xué)生物工程學(xué)院馮茜，骨]

● Cell Death & Disease (IF 9.0).Sun Y, et.al. (2023). METTL3 promotes colorectal cancer progression through activating JAK1/STAT3 signaling pathway.［山東第一醫(yī)科大學(xué)附屬腫瘤醫(yī)院 Lv-METTL3-gRNA、Lv-METTL3-shRNA、Lv-YTHDF1-shRNA 結(jié)直腸癌］

● BMC Biology（IF 5.4）.You WJ.（2023）. GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1.［浙江大學(xué)，Lv-shGadd45a，Lv-shCtrl.小鼠/豬皮下脂肪細(xì)胞.脂肪代謝］

● British Journal of Cancer，（IF 8.8）.Zhang SJ .（2023）. Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28.［山東大學(xué)第二醫(yī)院&山東大學(xué)齊魯醫(yī)院，靶向FOSL2和KRAS基因的shRNA干擾慢病毒，胰腺導(dǎo)管腺癌］

● Cellular and Molecular Life Sciences. (IF 8.0). Song et.al. (2023). FKBP5 deficiency attenuates calcium oxalate kidney stone formation by suppressing cell–crystal adhesion, apoptosis and macrophage M1 polarization via inhibition of NF-κB signaling. [武漢大學(xué)人民醫(yī)院、武漢大學(xué)技術(shù)科學(xué)研究所，AAV干擾載體、慢病毒過表達(dá)和干擾載體 腎臟]

● Cell Death and Differentiation. (IF 12.067). Liang et.al. (2023). The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway. [浙江大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院慢病毒干擾載體 pLent-shRNA-p62 肝臟]

● Metabolism Clinical and Experimental. (IF 13.934) Zhang et.al. (2022). ABCA1 deficiency-mediated glomerular cholesterol accumulation exacerbates glomerular endothelial injury and dysfunction in diabetic kidney disease. [四川大學(xué)華西醫(yī)院 pLent-RFP-shRNA-ABCA1 慢病毒干擾載體 糖尿病]

● Cell Death & Differentiation.（IF=12.067）.Zhang G , et.al. (2023). Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.［四川大學(xué)華西第二醫(yī)院、武漢大學(xué) pLent-shCT55 雄性不育］

● Journal of Agricultural and Food Chemistry.（IF=5.895）.Di-Ran，et.al.（2023）.Reactive Oxygen Species Control Osteoblast Apoptosis through SIRT1/PGC-1α/P53Lys382 Signaling, Mediating the Onset of Cd-Induced Osteoporosis.［揚(yáng)州大學(xué)Lv-SIRT1-shRNA干擾慢病毒 骨質(zhì)疏松］

● Angiogenesis.(IF=10.658 ).Weisi-Lu，et.al.（2022）.PDGFD switches on stem cell endothelial commitment.［中山大學(xué)中山眼科醫(yī)院 PDGFD過表達(dá)和敲低（4in1 shRNA）慢病毒載體 血管病干細(xì)胞治療］

● Journal of Cachexia, Sarcopenia and Muscle.（IF=12.063）.You W , et.al. (2022). Growth arrest and DNA damage-inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha.［浙江大學(xué)動(dòng)物科學(xué)學(xué)院 Lv-GADD45A-shRNA 肌內(nèi)脂肪沉積］

● Neurosci Bull.（IF=5.271）.Wang T, et.al. (2022). The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse.［北京大學(xué)第六醫(yī)院 LV-CRH-shRNA 睡眠障礙］

● Cancer Letters. (IF=9.756).Zongpan Jing, et.al.(2021).Acetylation-induced PCK isoenzyme transition promotes metabolic adaption of liver cancer to systemic therapy.[北京協(xié)和醫(yī)科大學(xué)腫瘤醫(yī)院 Lv-PCK2-shRNA 肝癌]

● Molecular Therapy: Nucleic Acids. (IF=10.183).Yu Zhang，et.al.(2021). Suppression of RNA editing by miR-17 inhibits the stemness of melanoma stem cells. [浙江大學(xué) Lv-DOCK2-shRNA & psPAX & PMD2.G質(zhì)粒 黑色素瘤干細(xì)胞]

● Cell Death and Disease. (IF=9.685).Xiaofang Chen，et.al.(2021). TCP1 increases drug resistance in acute myeloid leukemia by suppressing autophagy via activating AKT/mTOR signaling. [福建醫(yī)科大學(xué)附屬協(xié)和醫(yī)院 Lv-TCP1-shRNA 急性髓系白血病]

● Cell Death and Disease. (IF=9.685). Bo Sun，et.al.(2021). Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation. [中南大學(xué)湘雅醫(yī)院 Lv-PP2Ac-shRNA & Lv-PDCD10-shRNA 肝癌]

● Cancer Letters. (IF=9.756).Fang-Jing Zhong, et.al.(2021).STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFβ signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in hepatocellular carcinoma. [中南大學(xué)湘雅醫(yī)院 STMN2 3保1-shRNA 肝癌]

● Bioact Mater. (IF=14.593). Liu Y, et.al. (2021). DNA aptamer S11e recognizes fibrosarcoma and acts as a tumor suppressor. ［湖南大學(xué) Diablo/SMAC 3保1 shRNA慢病毒 纖維肉瘤］

● Cell Death & Disease. (IF=6.304). You, et al. (2020). GADD45α drives brown adipose tissue formation through upregulating PPARγ in mice.［浙江大學(xué) Lenti-sh-Gadd45a BAT cell & Ad-Gadd45a SVF細(xì)胞 肥胖］

● Journal of Neuroinflammation. (IF=5.793). Zeng, et al. (2019). Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury.［北京大學(xué)第三醫(yī)院 LV-SNCA-shRNA 脊髓損傷］

● Cell Discovery. (IF=6.255). Liao, et al. (2019). USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia.［廣州醫(yī)科大學(xué) pLent-4in1shRNA(For USP10/SKP2)-GFP & pLent-EF1a-FH-CMV-GFP containing SKP2-CDS, SKP2 (S72A) CML cells MOI=10 慢性粒細(xì)胞白血病CML］

● International Journal of Biological Sciences. (IF=4.858). Zheng, et al. (2019). Cathelicidin-related antimicrobial peptide protects against cardiac fibrosis in diabetic mice heart by regulating endothelial-mesenchymal transition.［鄭州大學(xué)附屬第一醫(yī)院lentiviruses-shAMPKa1 心肌注射 糖尿病性心肌?。?/a>

● Oncogene. (IF=7.971). Liao, et al. (2018). Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination.{廣州醫(yī)科大學(xué) pLent-4in1shRNA[For human USP14 (NM-005151)]-GFP 人乳腺癌細(xì)胞 MOI=10 雄激素受體陽性乳腺癌}

● J Mol Cell Cardiol. (IF= 4.133). Li, et al. (2017). TCONS_00075467 modulates atrial electrical remodeling by sponging miR-328 to regulate CACNA1C.［山東大學(xué)千佛山醫(yī)院 4in1shRNA慢病毒lenti-RNAi-TCONS_00075467 原代心肌細(xì)胞 心房顫動(dòng)AF的電重構(gòu)］

● International Journal of Molecular Sciences (IF=6.208). Yang D, et.al. (2023). Pharmacological T argeting of Bcl-2 Induces Caspase 3-Mediated  Cleavage of HDAC6 and Regulates the Autophagy Process in Colorectal Cancer.［重慶文理學(xué)院 Lv-mCherry-GFP-LC3B 結(jié)直腸癌］

● npj Biofilms and Microbiomes (IF=9.2). Li X, et.al. (2025). TSP50 deficiency in neural stem cells aggravates colitis in mice by altering intestinal microbiome. ［東北師范大學(xué) AAV-PHP.eB-TSP50  神經(jīng)干細(xì)胞中TSP50缺陷誘發(fā)的結(jié)腸炎］

● Science?(IF=45.8). Zheng Y, et.al. (2025). In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors. ［北京大學(xué) AAV9-hSyn-HaloDA1.0、AAV9-hsyn-hChR2(H134R)-mCherry、AAV9-EF1α-DIO-hChR2(H134R)-EYFP、AAV9-hSyn-NE2m、AAV9-hSyn-r5-HT1.0   遠(yuǎn)紅光多巴胺探針開發(fā)］

● Neuron?(IF=14.7). Shi Y, et.al. (2025). Non-image-forming photoreceptors improve visual orientation selectivity and image perception. ［中國科學(xué)技術(shù)大學(xué)&陸軍軍醫(yī)大學(xué)&深圳先進(jìn)技術(shù)研究院&清華大學(xué) AAV2/2-EF1a-DIO-GFP-WPRE-pA    視覺圖像感知］

● Nature Communications (IF 14.7) Wei et.al. (2025). A high-performance fluorescent sensor spatiotemporally reveals cell-type specific regulation of intracellular adenosine in vivo. [北京大學(xué)藥學(xué)院王晶教授聯(lián)合中國科學(xué)院遺傳與發(fā)育生物學(xué)研究所武照伐研究員及北京大學(xué)生命科學(xué)學(xué)院李毓龍教授團(tuán)隊(duì) AAV2/9-hSyn-HypnoS AAV2/9-hSyn-HypnoS-mut AAV5-GfaABC1D-HypnoS AAV5-GfaABC1D-HypnoS-mut 神經(jīng)]

●Nature Communications (IF 14.7) Chen et.al. (2024). Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance. [上海市第六人民醫(yī)院胡承、張燚 AAV-EF1α-DIO-Fam172a-EGFP 神經(jīng)]

● Journal of Advanced Research. (IF=11.4) Zhao et.al. (2024). Hippocampal dipeptidyl peptidase 9 bidirectionally regulates memory associated with synaptic plasticity. [中科院昆明動(dòng)物研究所周啟心團(tuán)隊(duì) AAV2/9-hSyn-DPP9-FLAG、AAV2/9-hSyn-GFP-WPRA、AAV2/9-CMV-Cas13d-FLAG-U6-2x gRNA DPP9、AAV2/9-CMV-Cas13d-FLAG-U6-2x gRNA NC 神經(jīng)]

● Acta Neuropathologica Communications. (IF=6.2) Lian et.al. (2024). Protein phosphatase 2Cm-regulated branched-chain amino acid catabolic defect in dorsal root ganglion neurons drives pain sensitization. [四川大學(xué)華西醫(yī)院呂沛林、李濤團(tuán)隊(duì) AAV9–hsyn-cre 神經(jīng)]

● Advanced Science(IF=14.3). Zhu Y, et.al. (2024). Adenosine-Dependent Arousal Induced by Astrocytes in a Brainstem Circuit. ［浙江大學(xué)腦科學(xué)與腦醫(yī)學(xué)學(xué)院  AAV2/5-GfaABC1D-hPMCA2w/b-mCherry、AAV2/5-GfaABC1D-mCherry、AAV2/9-hsyn-GRABAdo1.0、AAV2/9-hsyn-GRABAdo1.0mut、AAV2/9-hsyn-GRABATP1.0 、AAV2/5-GfaABC1D-ChrimsonR-mCherry  睡眠覺醒］

● Advanced Science (IF 14.3). Wang et.al. (2024). Endothelial Cells Mediated by STING Regulate Oligodendrogenesis and Myelination During Brain Development. [中國科學(xué)院大學(xué)焦建偉團(tuán)隊(duì)聯(lián)合四川大學(xué)華西醫(yī)院陳蕾團(tuán)隊(duì)、鄭州大學(xué)第一附屬醫(yī)院許予明團(tuán)隊(duì) 血管內(nèi)皮，AAV.BI30-FDFT1]

● Nature（IF=50.5）. Pascal S. Kaeser et.al. (2024). Dopamine dynamics are dispensable for movement but promote reward responses.［哈佛醫(yī)學(xué)院 AAV9-hSyn-GRABDA2m  多巴胺動(dòng)力學(xué)］

● npj Parkinson's Disease?(IF?6.7). Cao B et.al. (2024). PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease.［山東大學(xué) AAV9-α-syn、AAV9-siTFE3、AAV9-siTFEB、AAV9-PDCD4、AAV9-Ctrl 帕金森?。?/a>

● Cell Reports (IF 7.5). Li et.al. (2024). Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation. [四川大學(xué)華西醫(yī)院岑小波團(tuán)隊(duì) AAV2/8-CaMKII-mutant PDHA1-Flag 神經(jīng)]

● Journal of Neuroinflammation （IF 9.3）.Zhang WY.（2024）. Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering.［山東第一醫(yī)科大學(xué)附屬濟(jì)寧第一人民醫(yī)院, AAV9-U6-sh-AKAP8L，AAV9-U6-sh-NC，糖尿病相關(guān)認(rèn)知障礙］

● Nature Neuroscience (IF 21.2). Chen et.al. (2024). Spatiotemporally selective astrocytic ATP dynamics encode injury information sensed by microglia following brain injury in mice. [北京腦科學(xué)與類腦研究所井淼團(tuán)隊(duì) 神經(jīng) ]

● Cancer Cell (IF 50.3). Zhong et.al. (2024). Distinct roles of TREM2 in central nervous system cancers and peripheral cancers. [中山大學(xué)附屬第一醫(yī)院張弩團(tuán)隊(duì) 北京大學(xué)白凡團(tuán)隊(duì)，AAV9-F4/80-TREM2-flag-p2A-GFP，膠質(zhì)母細(xì)胞瘤]

● Environment International（IF 11.8）.Lin JH.（2024）. circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization.［南京醫(yī)科大學(xué)，AAV9-F4/80-miR30.shRNA-circADAMTS6，鼻滴 100 μL（5 × 10^11VP），每周1次，持續(xù)2周，肺氣腫］

● Neuron，（IF 16.2）.Feng JS.（2024）. Monitoring norepinephrine release in vivo using next-generation GRABNE sensors.［北京大學(xué)，AAV9-hSyn-GRABNE2m/NE2h，AAV9-Ef1a-DIO-C1V1-YFP，AAV9-GRABNE1m ，AAV9-GRABNE2m，AAV9-GRABNE2h，AAV9-hSyn-NE2m，AAV9-hSyn-NEmut .李毓龍實(shí)驗(yàn)室新升級第二代去甲腎上腺素探針］

● Molecular Psychiatry，（IF 13.437）.Wang CS .（2023）. Targeting PDK2 rescues stress-induced impaired brain energy metabolism.［山東第一醫(yī)科大學(xué)附屬濟(jì)寧市第一人民醫(yī)院，AAV9-hSyn-sh-NC，AAV9-hSyn-sh-GR，AAV9-hSyn-sh-PDK2，腦立體定位注射，抑郁癥］

● Nature Communications，（IF 16.6）.Zhan JB .（2023）. GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21.［浙江大學(xué)基礎(chǔ)醫(yī)學(xué)院與附屬邵逸夫醫(yī)院、、復(fù)旦大學(xué)腦科學(xué)轉(zhuǎn)化研究院、深圳華大生命科學(xué)研究院，AAV9-CaMKIIα-Cre-EGFP、AAV9-CaMKIIα-EGFP，腦立體定位注射、雙側(cè)扣帶回，神經(jīng)元衰老］

● Current Biology（IF=9.2）. Xinli Xu et.al. (2024). Hypothalamic CRF neurons facilitate brain reward function.［中國科學(xué)院深圳先進(jìn)技術(shù)研究院 AAV9-hSyn-DA4.4 獎(jiǎng)勵(lì)］

● Acta Pharmacologica Sinica（IF 8.2）.Cheng J.（2024）. Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice.［同濟(jì)大學(xué)，AAV9-hSyn-TPH2-P2A-GFP，8.89×10^13 V.G/mL ；AAV9-hSyn-GFP，7.71×10^13 V.G/mL；立體定位注射，DRN區(qū).1μL，1.11×10^9 V.G，0.2 μL /min］

● Cell Discovery (IF=33.5).Yang G et.al. (2024). TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons.［南京大學(xué)醫(yī)學(xué)院模式動(dòng)物研究所&鄭州大學(xué)附屬第一醫(yī)院&南京鼓樓醫(yī)院 AAV2/5-hSyn-DIO-GCaMP6s-P2A-nlsdTomato-hGH-pA、AAV2/5-CamKIIα-Cre-P2A-mCherry-WPRE-hGH-pA 渴覺］

● Developmental Cell (IF=11.8). Wang Y, et.al. (2023). BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development.［中國科學(xué)院動(dòng)物研究所AAV9-F4/80-GFP-mir30shRNA (Bach1)、AAV9-F4/80-GFP-mir30shRNA (control) 腦發(fā)育］

● ISCIENCE（IF=6.107）. Xia Q, et.al. (2023). SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced neuroinflammation after cerebral ischemia and reperfusion injury.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院 AAV2/6-U6-DIO-scramble control-EGFP、AAV2/6-U6-DIO-SENP3/shRNA-EGFP 缺血性腦卒中］

● Science，（IF 56.7）. Li Yulong.（2023）. A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors.［北京大學(xué), AAV9-hSyn-CRF1.0 ,AAV9-hSyn-CRFmut, AAV9-hSyn-CCK1.0,AAV9-hSyn-EGFP-CAAX，AAV9-hSyn-SST1.0，神經(jīng)遞質(zhì)探針］

● Nature Methods，（IF 48）. Li Yulong.（2023）. Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo.［北京大學(xué) ，AAV2/9-hSyn-gDA3m,AAV2/9-hSyn-gDA3h,AAV2/9-hSyn-gDA3mut,AAV2/9-hSyn-gDA2m,AAV2/9-hSyn-dLight1.3b,AAV2/9-hSyn-ACh3.0,AAV2/9-hSyn-eCB2.0,AAV2/9-hSyn-NE2m.多巴胺探針］

● JACC-Basic to Translational Science，（IF 9.531）. Zhu ZY.（2023）. Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis.［浙江大學(xué)醫(yī)學(xué)院附屬第二醫(yī)院，AAV9-cTnT-Myc-GDF-11，心臟，尾靜脈注射，心力衰竭］

● Molecular Neurobiology. (IF 5.68). Wang et.al. (2023). The circ_006573/miR?376b?3p Axis Advances Spinal Cord Functional Recovery after Injury by Modulating Vascular Regeneration. [上海交通大學(xué)醫(yī)學(xué)院附屬仁濟(jì)醫(yī)院 AAV干擾載體 AAV-circ_006573-shRNA 神經(jīng)]

● ISCIENCE（IF 6.107）.Li Xiao.et.al.（2023）. Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection［香港城市大學(xué) AAV-hSyn-CCK2.3 聽覺皮層，立體定位注射，神經(jīng)-皮層可塑性］

● BMC Biology. (IF=7.364). Wang Z, et.al. (2023). Neural ensembles in the murine medial prefrontal cortex process distinct information during visual perceptual learning.［中國科學(xué)技術(shù)大學(xué) AAV9-CaMKlla-GCaMP6f、AAV2/9-CaMKIIa-hM4Di-mCherry、AAV2/9-CaMKIIa-mCherry視知覺學(xué)習(xí)］

● The FASEB Journal. (IF 5.834). Yang et.al. (2023). Netrin-1 attenuates cerebral ischemia/reperfusion injury by limiting mitochondrial ROS and Ca2+ levels via activation of AKT phosphorylation and mitochondrial m- AAA protease AFG3L2. [上海交通大學(xué)醫(yī)學(xué)院 Ad-Netrin-1；Ad-Control；Ad-shNetrin-1；Ad-shControl AAV-Netrin-1；AAV-Control；AAV-U6-shNetrin-1；AAV-U6-shControl AAV腺病毒過表達(dá)和干擾載體 腦損傷]

● Phytomedicine. (IF 6.656) Ouyang et.al. (2023). Khellin as a selective monoamine oxidase B inhibitor ameliorated paclitaxel-induced peripheral neuropathy in mice. [南京中醫(yī)藥大學(xué) AAV-MAOB-shRNA AAV干擾載體 神經(jīng)]

● Lipocalin 2 in the Paraventricular Thalamic Nucleus Contributes to DSSInduced DepressiveLike Behaviors［浙江大學(xué)醫(yī)學(xué)院邵逸夫醫(yī)院AAV-CMV-shLcn2 丘腦室旁核（PVT），雙側(cè)注射 抑郁樣行為］

● Biomaterials. (IF 15.304) Lai et.al. (2023). Tail nerve electrical stimulation promoted the efficiency of transplanted spinal cordlike tissue as a neuronal relay to repair the motor function of rats with transected spinal cord injury. [中山醫(yī)學(xué)院 CNTF NT3 TrkC AAV過表達(dá)載體 神經(jīng)]

● iScience（IF=6.107）.Mahadi Hasan，et.al.（2023）.Chemogenetic activation of astrocytes promotes remyelination and restores cognitive deficits in visceral hypersensitive rats.［香港城市大學(xué) AAV8-GFAP-hM3D(Gq)-mCherry 認(rèn)知缺陷］

● Translational Psychiatry（IF=7.989）.Ya-Xin Sun ，et.al.（2023）.The causal involvement of the BDNF-TrkB pathway in dentate gyrus in early-life stress-induced cognitive deficits in male mice.［北京大學(xué)第六醫(yī)院 AAV2/9-CaMKIIa-Cre-P2A-GFP & AAV2/9-CaMKIIa-GFP 認(rèn)知障礙］

● Neurosci. Bull.(IF=5.271).SiYue-Qin，et.al.（2022）.REEP1 Preserves Motor Function in SOD1G93A Mice by Improving Mitochondrial Function via Interaction with NDUFA4.［山東大學(xué)基礎(chǔ)醫(yī)學(xué)院AAV1-hREEP1-Flag & AAV1-GFP 神經(jīng)退行性疾?。?/a>

● Neuron. (IF 18.688) Yang et.al. (2023). Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA. [約翰霍普金斯大學(xué) Gabrd AAV敲除載體 神經(jīng)]

● CELL MOL BIOL LETT. (IF 8.702) Zhonglin Cai et.al. (2022). ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood–testis barrier integrity. [中國醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)院 ALKBH5 AAV干擾載體 血睪屏障]

● Cell Reports.（IF=9.995）. Li H, et.al. (2022). β-hydroxybutyrate reduces reinstatement of cocaine conditioned place preference through hippocampal CaMKII-a β-hydroxybutyrylation.［四川大學(xué)華西醫(yī)院 AAV2/9-CaMKII-α-EGFP-Flag；AAV2/9-mutant CaMKII-α-EGFP-Flag  藥物成癮］

● NEURAL REGENERATION RESEARCH.（IF=6.058）.Shu Liu，et.al.（2022）.Knockdown of NADPH oxidase 4 reduces mitochondrial oxidative stress and neuronal pyroptosis following intracerebral hemorrhage［南方醫(yī)科大學(xué)珠江醫(yī)院 AAV9-shRNA-NOX4 和AAV9-CON  腦出血治療靶點(diǎn)］

● BMC biology.（IF=7.364）.Shu Liu，et.al.（2022）.Astrocytes in CA1 modulate schema establishment in the hippocampal-cortical neuron network.［香港城市大學(xué)AAV2/9-Ef1α-DIO-jGCaMp7s和AAV9-Syn-jGCaMp7s  CA1星形膠質(zhì)細(xì)胞］

● Nat Biotechnol. （IF=68.164）.Qian T, et.al. (2023). A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments.［北京大學(xué) AAV2/9-hSyn-OT1.0 ；AAV2/9-hSyn-OTmut；AAV2/9-hSyn-iGluSnFR (SF.iGluSnFR.A184V)；AAV2/9-CMV-BFP2-P2A-TeNT；AAV2/9-hSyn-DIO-PSD95-EGFP  催產(chǎn)素神經(jīng)遞質(zhì)］

● Neuron（IF=18.688）.Tian F, et.al.(2022).Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells. ［哈佛醫(yī)學(xué)院 小鼠gRNA AAV載體庫 神經(jīng)退行性疾病］

● Cell Reports.（IF=9.995）. Zhong C, et.al. (2022). A neural circuit from the dorsal CA3 to the dorsomedial hypothalamus mediates balance between risk exploration and defense. ［中國科學(xué)院深圳先進(jìn)技術(shù)研究院 AAV9-CaMKII-eArchT-EYFP&AAV9-Ef1a-DIO-eArch3.0-EYFP 危險(xiǎn)探索-防御行為］

● Journal of Neuroinflammation.（IF=9.578）.Fr?hlich A, et.al. (2022). Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury. ［烏爾姆大學(xué) AAV9-hSyn-TNFRSF11b-P2A-mCherry 創(chuàng)傷性腦損傷］

● Cell Rep.（IF=9.995）. Qi X, et.al. (2022). A nociceptive neuronal ensemble in the dorsomedial prefrontal cortex underlies pain chronicity. ［北京大學(xué) AAV2/9-TRE3G-mCherry；AAV2/9-TRE3G-hM3DGq-mCherry 慢性疼痛］

● Nature. （IF=69.504）.Breton-Provencher, V. et al. (2022). Spatiotemporal dynamics of noradrenaline during learned behaviour. ［麻省理工學(xué)院 AAV9-hSyn-DIO-GRABNE2m 習(xí)得行為］

● Neurobiology of Stress.（IF=7.142）.Zhou H, et al. (2022). The antidepressant effect of nucleus accumbens deep brain stimulation is mediated by parvalbumin-positive interneurons in the dorsal dentate gyrus. ［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院 AAV-EF1a-DIO-hM3Dq-mCherry & AAV-EF1a-DIO-hM4Di-mCherry 抑郁癥］

● CNS Neurosci Ther.（IF=7.035）.Yun Y, et al. (2022). Targeting upregulated RNA binding protein RCAN1.1: a promising strategy for neuroprotection in acute ischemic stroke. ［山東大學(xué)齊魯醫(yī)院 AAV9-R1SR13 & AAV9-R-CON；Lenti-RCAN1.1L-GFP & Lenti-siRCAN1.1-GFP & Lenti-R1SR13-GFP & Lenti-CON 急性缺血性卒中］

● Neuron.（IF=18.688）. Chi S, et.al. (2022). Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions. ［清華大學(xué) AAV2/9-GfaABC1D-ATP1.0 神經(jīng)再生和認(rèn)知］

● Cell Rep. （IF=9.995）.Dai B, et.al. (2022). Responses and functions of dopamine in nucleus accumbens core during social behaviors. ［紐約大學(xué)AAV9-hSyn-DIO-GRAB DA2m & AAV9-hSyn-loxP-GRAB DA2m -loxP 社會(huì)行為］

● Neurosci Bull.（IF=5.271）. Wang T, et.al. (2022). The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse.［北京大學(xué)第六醫(yī)院 AAV2/9-CAG-DIO-CRH-P2A-GFP 睡眠障礙］

● Mol Neurobiol.（IF=5.682）. Chen B, et.al. (2022). Celsr3 Inactivation in the Brainstem Impairs Rubrospinal Tract Development and Mouse Behaviors in Motor Coordination and Mechanic-Induced Response. ［暨南大學(xué) AAV9-CMV-GFP&scAAV1-hSyn-Cre 脊髓損傷］

● Neuropharmacology.（IF=5.273）. Wang T, et.al. (2022). Malfunction of astrocyte and cholinergic inputs is involved in postoperative impairment of hippocampal synaptic plasticity and cognitive function.［徐州醫(yī)科大學(xué) AAV-hSyn-GACh3.0 術(shù)后譫妄］

● Signal Transduction and Targeted Therapy.（IF=38.104）.Ling Zhang, et.al.（2021）.SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration.［中國醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院 AAV2-CMV-GFP & AAV9-CMV-GFP 血腦屏障］

● Nat Microbiol.（IF=30.964）.Boqiang Sun, et.al.（2021）.Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus-1 latency.［浙江大學(xué) AAV-CAG-Foxc1神經(jīng)元］

● NATURE COMMUNICATIONS.（IF=17.694）.Qian Wang, et.al.（2021）.Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice ［南方醫(yī)科大學(xué)AAV8-GFAP-hM3Dq-mCherry and AAV9-GfaABC1D-ATP1.0 自閉癥］

● Molecular Neurodegeneration.（IF=18.879）.Melanie Barth, et.al.（2021） Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures［德國神經(jīng)退行性疾病中心 AAV-hA53T-αS 小膠質(zhì)細(xì)胞］

● Protein Cell.（IF=15.328）.Xiaoyan Xu, et.al.（2021）. Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model［浙江大學(xué) AAV-CAG-Hsc70-WT & AAV-CAG-Hsc70 S85A阿爾茲海默癥］

● Cell Reports.（IF=9.995）. Zhuo Chen，et.al.（2021）. Deficiency of ER Ca²⁺ sensor STIM1 in AgRP neurons confers protection against dietary obesity.［華中科技大學(xué)AAV-EF1a-DIO-EGFP AgRP神經(jīng)元內(nèi)質(zhì)網(wǎng)Ca²⁺傳感器］

● MOL THER-NUCL ACIDS. (IF=8.886). Qianqian Cao, et.al. (2022). Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology.［暨南大學(xué) AAV9-hSyn-human SNCA 帕金森?。?/a>

● J Neuroinflammation. (IF=8.322). Huo S, et.al. (2021). Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice. ［南開大學(xué) AAV9-CaMKIIα-TRPC5 & AAV9-GFP 記憶障礙］

● Nature Neuroscience. (IF=20.071). Zhang, G.W., et al. (2021). Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior. ［南加州大學(xué) AAVretro-Cre 神經(jīng)元逆行標(biāo)記 焦慮與父母行為］

● Nature Communications. (IF=12.121). Xu, et.al. (2020). CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis.［中國科學(xué)院昆明動(dòng)物所 AAV9-shRNA(circGRIA1) & AAV9-shRNA(control) 靈長類動(dòng)物恒河猴腦衰老］

● Science Advances. (IF=13.116). Sun, et.al. (2020). Development of a CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain.［北京大學(xué) CRISPR-saCas9 基因編輯雄性SD大鼠特定神經(jīng)元群］

● The Journal of Neuroscience. (IF=5.673). Zingg B, et.al. (2020). Synaptic Specificity and Application of Anterograde Transsynaptic AAV for Probing Neural Circuitry.［南加利福尼亞大學(xué)scAAV1 hSyn-Cre & AAV1-hSyn-Flp & AAVretro-hSyn-Cre & AAV1-EF1a-DIO-Flp-WPRE & AAVretro-hSyn-GFP-WPRE 順向跨單級突觸示蹤］

● Molecular Psychiatry. (IF=12.384). li, et.al. (2020). Programmed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression.［山東大學(xué) AAV9-CMV-mPdcd4-P2A-GFP 抑郁癥］

● Biological Psychiatry. (IF=12.095). Zhang, et.al. (2020). Reduced neuronal cAMP in the nucleus accumbens damages blood-brain barrier integrity and promotes stress vulnerability.［中國藥科大學(xué) Dox 誘導(dǎo)性AAV2/9-shRNA-Adcy5 or AAV2/9-shRNA 抑郁癥］

● Cell Reports. (IF=8.109). Ma, et.al. (2019). Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation. ［北京大學(xué) AAV2 retro-hSyn-Cre-GFP & AAV2-CAG-DIO-BDNF-mCherry-3*flag 慢性疼痛］

● Cell. (IF=38.637). Fan, et.al. (2019). Stress-Induced Metabolic Disorder in Peripheral CD4+T Cells Leads to Anxiety-like Behavior. ［浙江大學(xué) AAV9-GFAP-GFP-miR30-shRNA(mAdora1) & AAV8-MBP-GFP-miR30-shRNA(mAdora1) & AAV8-MBP-GFP-miR30-shRNA(scramble) 焦慮精神疾?。?/a>

● Neuron. (IF=14.415). Feng, et.al. (2019). A Genetically Encoded Fluorescent Sensor for Rapid and Speci?c In Vivo Detection of Norepinephrine.［北京大學(xué)AAV9-hSyn-NE1m & NE1h and AAV9-hsyn-tTA 去甲腎上腺素神經(jīng)遞質(zhì)探針］

● Cell. (IF=38.637). Sun, et.al. (2018). A Genetically Encoded Fluorescent Sensor Enables Rapid and Speci?c Detection of Dopamine in Flies,Fish, and Mice.［北京大學(xué)AAV-hSyn-DA1m & DA1h 多巴胺神經(jīng)遞質(zhì)探針］

● Behavioural Neurology. (IF=2.093). Qu, et.al. (2018). MST1 Suppression Reduces Early Brain Injury by Inhibiting the NF-κB/MMP-9 Pathway after Subarachnoid Hemorrhage in Mice.［第三軍醫(yī)大學(xué)西南醫(yī)院神經(jīng)外科 MST1 AAV-4 in 1 shRNA-GFP 腦室注射 蛛網(wǎng)膜下腔出血］

● Neuron. (IF=14.415). Zingg B, et.al. (2017). AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors.［南加利福尼亞大學(xué)AAV1-EF1a-DIO-Flp 順向跨單級突觸示蹤］

● Redox Biology?(IF=10.7)?.Fu J, et.al. (2025). PDE4D inhibition ameliorates cardiac hypertrophy and heart failure by activating mitophagy.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院 AAV9-cTNT-PDE4D5、AAV9-NC  心力衰竭］

● Nature Communications (IF 14.7) Wang et.al. (2025). Serpina3k lactylation protects from cardiac ischemia reperfusion injury. [中國醫(yī)學(xué)科學(xué)院阜外醫(yī)院胡盛壽院士、周冰瑩 AAV9-FSP1-SA3K-WT AAV9-FSP1-SA3K-K351R 心臟缺血損傷]

● Cardiovascular Diabetology (IF=8.5).Wang R, et.al. (2024). Fibroblast growth factor 21 improves diabetic cardiomyopathy by inhibiting ferroptosis via ferritin pathway.［暨南大學(xué)第一附屬醫(yī)院 AAV9-FGF21、AAV9-GFP；AAV9-shFGF21、AAV9-Con  糖尿病心肌?。?/a>

● Cardiovascular Research. (IF=10.2) Che et.al. (2024). Cardiac tumour necrosis factor receptor-associated factor 7 mediates the ubiquitination of apoptosis signal-regulating kinase 1 and aggravates cardiac hypertrophy. [武漢大學(xué)人民醫(yī)院唐其柱團(tuán)隊(duì) AAV9-cTNT-Traf7、AAV9-cTNT-GFP 心臟肥大]

● Experimental & Molecular Medicine（IF 9.5）.Xian GP.（2024）. Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions.［南方醫(yī)科大學(xué) , AAV2-circHIPK3、AAV2-vector，主動(dòng)脈瓣鈣化?。?/a>

● Cell Death and Disease（IF 8.1）.Zhen J.（2024）. Histone acetyltransferase Kat2a regulates ferroptosis via enhancing Tfrc and Hmox1 expression in diabetic cardiomyopathy.［吉林大學(xué)第一醫(yī)院尉海濤，AAV9-Alkbh5，AAV9-shAlkbh5；AAV9-Hmox1，AAV9-shHmox1；AAV9-Ythdf2，AAV-shYthdf2；AAV9-Kat2a，AAV9-shKat2a；AAV9-Trfc， AAV9-shTrfc；AAV9-GFP，AAV9-shNC，糖尿病心肌?。?/a>

● Signal Transduction and Targeted Therapy (IF 40.8). Chen et.al. (2024). PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis. [中國醫(yī)學(xué)科學(xué)院胡盛壽/李向杰/宋江平 心肌纖維化]

● Molecular Therapy (IF 12.4). Xie et.al. (2024). Nuclear AGO2 promotes myocardial remodeling by activating ANKRD1 transcription in failing hearts. [華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院，AAV9-cTNT-AGO2 NLS，AAV9-cTNT-AGO2 NES，AAV9-cTNT-shAGO2，AAV9-cTNT-shANKRD1，心力衰竭]

● Advanced Science (IF 15.1). Guo et.al. (2023). NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post-Myocardial Infarction via Human Antigen R. [山東大學(xué)齊魯醫(yī)院，AAV9-FSP1-NKRF、AAV9-FSP1-HuR、AAV9-FSP1-shHuR、Ad-NKRF，Ad-HuR 心肌梗死]

● Adv. Sci.（IF 15.1）.Cao XY.（2024）. Role of Argininosuccinate Synthase 1 -Dependent L-Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against Atherosclerosis.［香港中文大學(xué)，AAV8-HCRApoE-hAAT-mPCSK9，尾靜脈注射，2.5×10^11 vg/mouse.動(dòng)脈粥樣硬化造模］

● Acta Pharmaceutica Sinica B（IF 14.5）. Yu W, et.al. (2023). Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis.［中山大學(xué)藥學(xué)院 AAV9-shTFRC、AAV9-shNC 三到五點(diǎn)心肌注射 心肌?。?/a>

● Free Radical Biology and Medicine. (IF 7.4). Zhang et.al. (2023). Frataxin inhibits the sensitivity of the myocardium to ferroptosis by regulating iron homeostasis. [第四軍醫(yī)大學(xué)基礎(chǔ)醫(yī)學(xué)院、第四軍醫(yī)大學(xué)西京醫(yī)院，AAV和腺病毒過表達(dá)載體AAV9-cTNT-frataxin，Ad-Frataxin 心臟]

● Journal of Molecular Medicine，（IF 5.606）. Shao SY.（2023）. Never in mitosis gene Arelated kinase6 deficiency deterioratesdiabetic cardiomyopathy via regulating heat shock protein 72.［鄭州大學(xué)第一附屬醫(yī)院Ad-NEK6，MOI=50，心肌細(xì)胞，糖尿病心肌?。?/a>

● Journal of Molecular Medicine. (IF=5.606). Wu L, et.al. (2023). TRIM-containing 44 aggravates cardiac hypertrophy via TLR4/NOX4-induced ferroptosis.［鄭州大學(xué)第一附屬醫(yī)院AAV9-cTnT-TRIM44、AAV9-cTnT-shTRIM44 心肌肥厚］

● Oxidative Medicine and Cellular Longevity. (IF=7.310). Li WJ, et.al. (2023). Cryptotanshinone Attenuated Pathological Cardiac Remodeling In Vivo and In Vitro Experiments. ［武漢大學(xué)人民醫(yī)院AAV9-STAT3 & AAV9-GFP 心臟重塑］

● Cell Reports. (IF=8.8). Zou J, et.al. (2023). Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation. ［奧古斯塔大學(xué)AAV9-cTnT-Cre-WPRE 心臟成熟］

● Cells. (IF=7.666) Fangfang Li et.al. (2022). KLF9 Aggravates Streptozotocin-Induced Diabetic Cardiomyopathy by Inhibiting PPARγ/NRF2 Signalling. [徐州醫(yī)科大學(xué)附屬醫(yī)院 KLF9 AAV過表達(dá)和干擾載體 糖尿病性心肌病]

● cells.（IF=7.666）. Chen Z, et.al. (2022). TMEM43 Protects against Sepsis-Induced Cardiac Injury via Inhibiting Ferroptosis in Mice. ［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院武漢中心醫(yī)院 AAV9-cTNT-TMEM43；AAV9-cTNT-shTMEM43 膿毒癥性心肌?。?/a>

● Sci Adv. (IF=14.136). Bi HL, et.al. (2022). The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor. ［大連醫(yī)科大學(xué)附屬醫(yī)院 rAAV9-CMV-UCHL1 & rAAV9-CMV-GFP 心肌肥厚］

● ACTA PHARM SIN B. （IF=14.903）. Wu X, et al. (2022). Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS. ［中國藥科大學(xué) AAV9-cTnT-shPKM2 & AAV9-cTnT-wildtype PKM2 & AAV9-cTnT-mutants PKM2 心肌缺血］

● Mol Ther. (IF=12.910). Zheng H, et al. (2022) . CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output. ［南方醫(yī)科大學(xué) AAV9-circSamd4&AAV9-NC 心肌梗死］

● FRONT CARDIOVASC MED. (IF=7.419).Xin Huang , et.al. (2021). Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology.［首都醫(yī)科大學(xué) AAV9-Sfrp5心肌梗死］

● MOL THER-NUCL ACIDS. (IF=8.886). Xiang He, et.al. (2021). CircRNA Chordc1 protects mice from abdominal aortic aneurysm by contributing to the phenotype and growth of vascular smooth muscle cells. ［南方醫(yī)科大學(xué)南方醫(yī)院 AAV9-circChordc1-shRNA & AAV9-Scr 腹主動(dòng)脈瘤］

● Theranostics. (IF=11.556). Hao Li, et.al. (2021). Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)–induced dissecting abdominal aortic aneurysm . ［中國醫(yī)學(xué)科學(xué)院阜外醫(yī)院 AAV9-LH1-P2A-GFP & AAV9-GFP 腹主動(dòng)脈瘤］

● J Mol Med (Berl). (IF=4.599). Li F, et.al. (2021). Zinc finger and BTB domain-containing protein 20 aggravates angiotensin II-induced cardiac remodeling via the EGFR-AKT pathway. ［徐州醫(yī)科大學(xué)附屬醫(yī)院 AAV9-ZBTB20 & AAV9-shZBTB20 心臟重構(gòu)］

● Hypertension. (IF=7.713). Liu, Wen, Li, et.al. (2020). Oleic Acid Attenuates Ang II（Angiotensin II）-Induced Cardiac Remodeling by Inhibiting FGF23（Fibroblast Growth Factor 23.［中國醫(yī)學(xué)科學(xué)院阜外醫(yī)院 AAV9-Fgf23&AAV9-GFP 高血壓心臟重構(gòu)］

● International Journal of Molecular Medicine. (IF=3.098). Huang, et.al. (2019). Redd1 protects against post-infarction cardiac dysfunction by targeting apoptosis and autophagy.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院 AAV9-Redd1 & AAV9-GFP 心肌梗死MI］

● Frontiers in Pharmacology. (IF=4.225). Shen, et.al. (2019). Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib.［河北醫(yī)科大學(xué) AAV9-cTNT-GFP-miR-146a & AV-miR-146a SNT-誘導(dǎo)的心臟收縮障礙］

● Journal of Molecular and Cellular Cardiology. (IF=4.133). Wu, et.al. (2019). The protective effect of high mobility group protein HMGA2 in pressure overload-induced cardiac remodeling.［武漢大學(xué) AAVs & Ads心臟重構(gòu)］

● Biochemical and Biophysical Research Communications. (IF=2.985). Yang, et.al. (2018). Vaspin alleviates myocardial ischaemia/reperfusion injury via activating autophagic ?ux and restoring lysosomal function.［山東大學(xué)齊魯醫(yī)院 AAV-vaspin & Ad-RFP-GFP-LC3 心臟］

● Acta Pharmaceutica Sinica B?(IF=14.6). Li J, et.al. (2025). IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia.［中國醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院&中國科學(xué)技術(shù)大學(xué)  AAV-PCSK9  高膽固醇血癥和動(dòng)脈粥樣硬化］

● Acta Pharmaceutica Sinica B?(IF=14.7). Ye W, et.al. (2025). Dihydromyricetin mitigates abdominal aortic aneurysm via transcriptional and posttranscriptional regulation of heme oxygenase-1 in vascular smooth muscle cells.［暨南大學(xué)&廣東醫(yī)科大學(xué) AAV2-SM22α-miR30-shHmox1、AAV2-SM22α-miR30-shCtrl  腹主動(dòng)脈瘤］

● Advanced Science (IF=14.3). Cui X, et.al. (2024). ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure.［山東大學(xué)齊魯醫(yī)院&哈爾濱醫(yī)科大學(xué)附屬第二醫(yī)院 AAV9-SM22α-shRGS2；AAV9-SM22α-shZFP36；AAV9-CTR shRNA  高血壓］

● Nature Communications?(IF=14.7)?.Liu Y, et.al. (2025). E3 ubiquitin ligase RNF128 promotes Lys63-linked polyubiquitination on SRB1 in macrophages and aggravates atherosclerosis.［山大齊魯醫(yī)院&山大基礎(chǔ)醫(yī)學(xué)院 AAV-PCSK9  動(dòng)脈粥樣硬化］

● Metabolism (IF 10.8)  Liu et.al. (2024). Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I. [天津醫(yī)科大學(xué)付成來、朱毅AAV-mPCSK9  心血管]

● Acta Pharmacologica Sinica ( IF 6.9 ). Zheng et.al. (2024). Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol. [暨南大學(xué)藥學(xué)院劉志平團(tuán)隊(duì)、中山大學(xué)藥學(xué)院劉培慶團(tuán)隊(duì) 血管內(nèi)皮細(xì)胞衰老]

● Phytomedicine （IF 7.9）. Zou J, et.al. (2024). Targeting the smooth muscle cell KEAP1-Nrf2-STING axis with pterostilbene attenuates abdominal aortic aneurysm.［暨南大學(xué)&廣東醫(yī)科大學(xué) AAV2-SM22α-shNrf2、AAV2-sh-control 腹主動(dòng)脈瘤］

● BMC Medicine (IF 9.3). Sheng Y, et.al. (2023). Tomo-seq identifies NINJ1 as a potential target for anti-inflammatory strategy in thoracic aortic dissection.［廣州市第一人民醫(yī)院、中國醫(yī)學(xué)科學(xué)院阜外醫(yī)院 AAV9-U6-shNinj1、AAV9-NC 眶后靜脈注射 胸主動(dòng)脈夾層］

● Cell Death & Disease. (IF 9.0). Deng et.al. (2023). Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6. [山東大學(xué)齊魯醫(yī)院，AAV干擾載體、AAV-PCSK9 動(dòng)脈粥樣硬化]

● Autophagy. (IF=13.391). Chen Z, et.al. (2022). Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy. ［中國醫(yī)學(xué)科學(xué)院阜外醫(yī)院 rAAV8-HCRApoE/hAAT-D377Y-mPCSK9 動(dòng)脈粥樣硬化］

● Theranostics. (IF=11.600) .Hao Li, et.al.（2021）. Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)–induced dissecting abdominal aortic aneurysm. [北京協(xié)和醫(yī)科大學(xué)AAV9-LH1&AAV9-GFP 腹主動(dòng)脈瘤]

● Molecular Therapy: Nucleic Acids. (IF=10.183).Xiang He，et.al.(2021). CircRNA Chordc1 protects mice from abdominal aortic aneurysm by contributing to the phenotype and growth of vascular smooth muscle cells. [南方醫(yī)科大學(xué) AAV-circChrodc1-shRNA 腹主動(dòng)脈瘤]

● Biomed Pharmacother. (IF=6.529). Wu Y, et.al. (2022). Endothelium-targeted delivery of PPARδ by adeno-associated virus serotype 1 ameliorates vascular injury induced by hindlimb ischemia in obese mice. ［香港中文大學(xué) AAV-Vector & AAV-ICAM2-Ppard 下肢缺血］

● J ADV RES. (IF=10.479). Chak Kwong Cheng, et.al. (2022). SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis. ［香港中文大學(xué) AAV-Vector & AAV-ICAM2-SOX4 動(dòng)脈粥樣硬化］

● Arteriosclerosis, Thrombosis, and Vascular Biology. (IF=6.604). Zhao, et.al. (2019). ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension.［山東大學(xué)齊魯醫(yī)院 AAV2-SM22α-ALDH2 & AAV1-ICAM2-ALDH2 低氧性肺動(dòng)脈高壓HPH］

● Journal of Molecular and Cellular Cardiology. (IF=4.133). Sun, et.al. (2019). LncRNA H19 promotes vascular inflammation and abdominal aortic aneurysm formation by functioning as a competing endogenous RNA.［南方醫(yī)科大學(xué)南方醫(yī)院 AAV9-H19 腹主動(dòng)脈瘤AAA］

● Journal of Cerebral Blood Flow & Metabolism. (IF=5.681). Li, et.al. (2019). Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice.［中國醫(yī)學(xué)科學(xué)院阜外醫(yī)院 AAV9-LH3-p2A-GFP 高血壓性腦出血ICH］

● Arteriosclerosis, Thrombosis, and Vascular Biology. (IF=6.604). Zhong, et.al. (2019). SM22α (Smooth Muscle 22α) Prevents Aortic Aneurysm Formation by Inhibiting Smooth Muscle Cell Phenotypic Switching Through Suppressing Reactive Oxygen Species/NF-κB (Nuclear Factor-κB).［南方醫(yī)科大學(xué)南方醫(yī)院 AAV9-SM22α 腹主動(dòng)脈瘤AAA］

●Advanced Science(IF=14.3).Yan H, et.al. (2025). Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity.［浙江大學(xué) AAV8-TBG-NC、AAV8-TBG-shSqle 克唑替尼肝毒性］

●Acta Pharmaceutica Sinica B (IF 14.7) Guo et.al. (2025). Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1dependent epigenetic modulation of NADPH oxidase 4. [山東大學(xué)齊魯醫(yī)學(xué)院顧俊蓮 AAV8-TBG-CTL、AAV8-TBG-shNox4、AAV8-TBG-Sirt1 肝臟]

●Cell Reports (IF=7.5).Xue C, et.al. (2024). Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.［中國科學(xué)技術(shù)大學(xué)/北京協(xié)和醫(yī)學(xué)院/合肥工業(yè)大學(xué) AAV8-TBG-EGFP-miR30-shNogo-B、AAV8-TBG-EGFP-miR30-shControl 膽固醇代謝］

●Nature Communications?(IF=14.7).Yang X, et.al. (2024). FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early liver graft injury.［浙江大學(xué)轉(zhuǎn)化醫(yī)學(xué)研究院/浙江省人民醫(yī)院 AAV8-TBG-Alox15 shRNA 肝移植損傷］

●Journal of Hematology & Oncology (IF 29.5). Wang et.al. (2024). METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma. [上海東方醫(yī)院高勇/李硯東團(tuán)隊(duì) AAV8-TBG-Cre 肝細(xì)胞癌]

●Signal Transduction and Targeted Therapy（IF 40.8）.Yan H.（2024）. Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis.［北大基礎(chǔ)醫(yī)學(xué)院，北大人民醫(yī)院,吉林大學(xué),吉林大學(xué)第一醫(yī)院,AAV8-RIMKLA，AAV8-GFP，非酒精性脂肪性肝病］

●Military Medical Research (IF 16.7).Hu CQ, et.al. (2024). PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis.［北大基礎(chǔ)醫(yī)學(xué)院/北大人民醫(yī)院/吉林大學(xué)第一醫(yī)院 AAV8-CMV-FAM3A、AAV8-CMV-GFP 肝臟糖脂代謝］

●Cell Reports Medicine（IF 14.3）.Zhu WZ.（2024）. Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation.［上海中醫(yī)藥大學(xué)、湖州市中心醫(yī)院，AAV8-TBG-A1R，AAV8-TBG-GFP，尾靜脈注射，10^12vg per mice，肝臟MASH］

●Cell Death & Disease (IF 9.0). Li et.al. (2023). Gp78 deficiency in hepatocytes alleviates hepatic ischemiareperfusion injury via suppressing ACSL4-mediated ferroptosis. [浙江大學(xué)醫(yī)學(xué)院徐驍/劉治坤/王迪團(tuán)隊(duì)，AAV8-TBG-gp78，肝臟］

●Journal of Lipid Research.（IF=6.5）.Yang Z, et.al. (2024). Histone demethylase KDM1A promotes hepatic steatosis and inflammation by increasing chromatin accessibility in NAFLD.［武漢大學(xué)人民醫(yī)院、贛南醫(yī)科大學(xué) AAV8-sgKDM1A 非酒精性脂肪肝］

●Redox Biology（IF 11.4）.Yuan JT.（2024）. DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis.［中國科學(xué)院大學(xué)、北京朝陽醫(yī)院、美國密西西比大學(xué)，AAV8-TBG-Prdx1，AAV8-TBG-GFP . 尾靜脈注射，1.1×10^12 vg/mouse］

●Journal of Translational Medicine. (IF=7.4).Yang L, et.al. (2024). ANGPTL3 is a novel HDL component that regulates HDL function.［首都醫(yī)科大學(xué)附屬北京潞河醫(yī)院 AAV2/8-ANGPTL3、AAV2/8-vector、AAV2/8-shANGPTL3、AAV2/8-shNC  2型糖尿?。?/a>

●Acta Pharmaceutica Sinica B (IF=14.5). Huang ZF, et.al. (2023). FGF4 protects the liver from immune-mediated injury by activating CaMKKb-PINK1 signal pathway to inhibit hepatocellular apoptosis.［溫州醫(yī)科大學(xué)附屬第一醫(yī)院 AAV8-TBG-shFGFR4、AAV8-TBG-shPINK1 免疫性肝損傷］

●Cell Death & Disease (IF=9.685). Tao X, et.al. (2023). Genetic deletion of phosphodiesterase 4D in the liver improves kidney damage in high-fat fed mice: liver-kidney crosstalk.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院 AAV8-TBG-PDE4D、AAV8-GFP； 非酒精性脂肪性肝?。?/a>

●ACTA PHARM SIN B（IF=14.903）.Shen X, et.al. (2023). Hepatic DDAH1 mitigates hepatic steatosis and insulin resistance in obese mice:Involvement of reduced S100A11 expression.［中國科學(xué)院大學(xué)AAV8-TBG-hDDAH1、AAV8-His；AAV8-shS100a11、AAV8-GFP； 非酒精性脂肪性肝?。?/a>

●International Journal of Molecular Sciences. (IF 6.208). Chen et.al. (2023). Sleeve Gastrectomy Improves Hepatic Glucose Metabolism by Downregulating FBXO2 and Activating the PI3K-AKT Pathway. [山東大學(xué)齊魯醫(yī)院 AAV過表達(dá)載體 AAV-TBG-FBXO2 肝臟]

●Molecular Therapy: Nucleic Acid（IF 8.8）. Yang XS.（2023）.PPM1H is down-regulated by ATF6 and dephosphorylates p-RPS6KB1 to inhibit 1 progression of hepatocellular carcinoma［中國醫(yī)學(xué)科學(xué)院 AAV8-PPM1H，AAV8-control 尾靜脈注射，肝臟］

● Acta Pharmaceutica Sinica B. (IF 14.903). Zhu et.al. (2023). The E3 ubiquitin ligase NEDD4-1 protects against acetaminopheninduced liver injury by targeting VDAC1 for degradation. [吉林大學(xué)動(dòng)物醫(yī)學(xué)院 AAV過表達(dá)和干擾載體 肝臟]

● Nature Communications. (IF 17.694) Xiao et.al. (2023). Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice. [復(fù)旦大學(xué)腦科學(xué)轉(zhuǎn)化研究院 PREP AAV過表達(dá)載體 肝臟和脂肪產(chǎn)熱］

● Cell Biol Toxicol（IF=6.819）.Chen X, et.al. (2022). Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress. ［中國藥科大學(xué)AAV8-siSTING & AAV8-control 肝毒性］

● Metabolism（IF=13.934）.Yan H, et.al. (2022). FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP Synthase.［北京大學(xué)醫(yī)學(xué)部基礎(chǔ)醫(yī)學(xué)院AAV8-U6-shFOXD3 &AAV8-U6-GFP（pAV-3in1-shRNA-GFP ）  代謝性疾?。?/a>

● Hepatology. (IF=17.298). Wang T, et.al. (2022). Cellular heterogeneity and transcriptomic profiles during intrahepatic cholangiocarcinoma initiation and progression. ［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院&西安交通大學(xué) AAV8-CRISPR/sgZmiz1 &AAV8-CRISPR/sgYbx1 肝內(nèi)膽管細(xì)胞癌］

● Cell Metabolism.(IF=31.373) . Lin Wang, et.al.（2021）. Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1.［第四軍醫(yī)大學(xué)西京醫(yī)院肝膽外科 AAV8-TRIM16 & AAV8-GFP 非酒精性脂肪性肝炎］

● Cell Metab. (IF=27.287). Wang L, et.al. (2021). Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1. ［第四軍醫(yī)大學(xué)西京醫(yī)院 AAV8-CMV-TRIM16&AAV8-CMV-GFP 非酒精性脂肪性肝炎］

● Hum Cell. (IF=4.174). Chen S, et.al. (2021). Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination. ［杭州醫(yī)學(xué)院附屬人民醫(yī)院 AAV8-TBG-RNF20 肝纖維化］

● Proc. Natl. Acad. Sci. U.S.A. (PNAS). (IF=9.412). Zhang, et.al. (2020). Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation.［中國人民解放軍軍事醫(yī)學(xué)科學(xué)院 & 南開大學(xué) AAV-DJ-CAG-Cre II型戊二酸尿癥GA-II］

● Journal of Hepatology. (IF=20.582). She, et.al. (2019). PSMP/MSMP promotes hepatic ?brosis through CCR2 and represents a novel therapeutic target.［北京大學(xué)基礎(chǔ)醫(yī)學(xué)院 AAV8-hPSMP & null 肝纖維化］

● Theranostics. (IF=8.579). Liu, et.al. (2019). Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration.［浙江大學(xué) AAV9-CMV-YAP 肝再生］

● Molecular Cell. (IF=15.584). Wan, et.al. (2019). Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.［浙江大學(xué) AAV9-mCherry-GFP-LC3 and AAV9-Pacerwt-HA&Pacer2KR-HA&PacerS157A-HA&PacerS157D-HA 肝自噬和脂代謝］

● Experimental Cell Research. (IF=3.383). Li, et.al. (2018). Brg1 promotes liver fibrosis via activation of hepatic stellate cells.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院 AAV8-shBrg1 or AAV8-GFP 肝纖維化］

● Molecular Cell. (IF=15.584). Wan, et.al. (2018). mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.［浙江大學(xué) AAV9-shHUWE1 & shNC and AAV9-WIPI2&WIPI2-S395A&WIPI2-S395D 肝自噬］

● Molecular Cell. (IF=15.584). Su, et.al. (2017). VPS34 Acetylation Controls Its Lipid Kinase Activity and the Initiation of Canonical and Non-canonical Autophagy.［浙江大學(xué) AAV9-CMV-VPS34&3KR&3KQ 肝自噬］

● Proc. Natl. Acad. Sci. U.S.A. (PNAS). (IF=9.412). He, et.al. (2017). MicroRNA-351 promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptor.［第二軍醫(yī)大學(xué) AAV8-CMV-eGFP-miR-351-5p Sponge 血吸蟲病肝纖維化］

● Cell Reports (IF 8.8). Nan et.al. (2023). m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1α activation. [中國醫(yī)學(xué)科學(xué)院劉芝華/李印團(tuán)隊(duì)，AAV-shLINK-A，AAV-shCtrl，食管癌]

● MOLECULAR THERAPY.（IF=12.910）. Nan Y, et.al. (2022). HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity.［中國醫(yī)學(xué)科學(xué)院腫瘤醫(yī)院 AAV-shHCP5 & AAV-shCtrl 食管鱗癌］

● Cell Death & Disease?(IF?9.0).Li YT, et.al. (2023). Targeting LGSN restores sensitivity to chemotherapy in gastric cancer stem cells by triggering pyroptosis.［深圳大學(xué)醫(yī)學(xué)部 AAV9-shLGSN、AAV9-shNTC 胃癌］

● Cell Death & Disease (IF=8.1). Shao L, et.al. (2024). FXR-regulated COX6A2 triggers mitochondrial apoptosis of pancreatic β-cell in type 2 diabetes.［深圳大學(xué)醫(yī)學(xué)部 AAV9-CMV-SaCas9-3xHA-U6-sgCox6a2、AAV9-vector 2型糖尿?。?/a>

● Nature Communications（IF 16.6）.Zhang H.（2024）. ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression.［中南大學(xué)湘雅二醫(yī)院、華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院，AAV8-shZDHHC20，AAV8-shControl ，腹腔注射100 μL/mouse，胰腺癌］

● Acta Pharmaceutica Sinica B（IF 14.5）. Liu Y, et.al. (2023). A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer.［中國藥科大學(xué) AAV-shGSDME、AAV-shC 瘤內(nèi)注射 胰腺導(dǎo)管腺癌］

● Cellular and Molecular Life Sciences，（IF 9.207）. Zhao Xingqi.（2023）. Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1.［南京師范大學(xué)，AAV8-SYT7 & AAV8-null，胰腺導(dǎo)管內(nèi)注射］

● ISCIENCE. (IF 6.107). Guo et.al. (2023). Steroidogenic factor 1 protects mice from obesity-induced glucose intolerance via improving glucose-stimulated insulin secretion by beta cells. [中山大學(xué)附屬第一醫(yī)院 AAV和腺病毒過表達(dá)載體 胰腺]

● Digestive Diseases and Sciences .（IF=3.487）.XiaoYu Yang，et.al.（2021）.MiR155 Disrupts the Intestinal Barrier by Inducing Intestinal Inflammation and Altering the Intestinal Microecology in Severe Acute Pancreatitis.［南昌大學(xué)第一附屬醫(yī)院AAV9-miR155和AAV9-miR155 sponge胰腺炎］

● Nature Communications（IF17.694）.Cheng R, et.al. (2023). Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity.［中國藥科大學(xué)&東南大學(xué)AAV8-MIP (mouse insulin1 promoter)-circGlis3 糖尿?。?/a>

● Cell Research.（IF=46.297）.Cheng R, et.al. (2022). A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers.［中山大學(xué)第一附院&蘇州大學(xué)&南京大學(xué)AAV9-shRNA-RASON&AAV9-shRNA-NC  KRAS突變癌］

● Clinical Cancer Research. (IF13.801). Ding et.al. (2023). A Tumor-suppressive Molecular Axis EP300/circRERE/ miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer. [廈門大學(xué)第一附屬醫(yī)院 AAV-CMV-circRNA-mCMV-copGFP AAV過表達(dá)載體 癌癥]

● J Immunother Cancer .（IF=12.461）.Chao Liu，et.al.（2021）.Blocking IL- 17A enhances tumor response to anti- PD-1 immunotherapy in microsatellite stable colorectal cancer.［哈爾濱醫(yī)科大學(xué)附屬腫瘤醫(yī)院AAV-miR-15b-5p sponge結(jié)直腸癌］

● Cancer Lett.（IF=9.756）.SiMiao Qiao，et.al.（2020）.Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer.［中國藥科大學(xué)AAV9-CPT1 & AAV9-control 結(jié)直腸炎］

● Nature Cell Biology (IF 17.3) Chen et.al. (2025). Rpl12 is a conserved ribophagy receptor. [浙江大學(xué)易聰、鄒煒團(tuán)隊(duì)，廣州醫(yī)科大學(xué)馮杜團(tuán)隊(duì)、國科大杭州高等研究院黃云鵬團(tuán)隊(duì)聯(lián)合天津大學(xué)梅坤榮 rAAV9-RPL12-WT、rAAV9-RPL12 P3N-E21L 核糖體穩(wěn)態(tài)]

● Nature Metabolism (IF 18.9). Zheng et.al. (2024). S-acylation of ATGL is required for lipid droplet homoeostasis in hepatocytes. [浙江大學(xué)醫(yī)學(xué)院附屬第四醫(yī)院Dante Neculai、劉偉團(tuán)隊(duì)聯(lián)合加拿大多倫多大學(xué)Brian Raught團(tuán)隊(duì)和加拿大戴爾豪斯大學(xué)Gregory D. Fairn團(tuán)隊(duì) 脂肪代謝]

● Circulation，（IF 37.8）.Zhan JB .（2023）. Ago2 protects against diabetic cardiomyopathy via activating mitochondrial gene translation.［華中科技大學(xué)附屬同濟(jì)醫(yī)院心血管內(nèi)科，AAV9-cTNT-NLS-Ago2，AAV9-cTNT-NES-Ago2，AAV9-cTNT-COX8-Ago2，AAV9-cTNT-shRNA-Ago2，尾靜脈注射，糖尿?。?/a>

●Metabolism，（IF 9.8）.Hu YT.（2023）. Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation.［北京大學(xué)醫(yī)學(xué)部基礎(chǔ)醫(yī)學(xué)院、北京大學(xué)人民醫(yī)院，AAV8-FPR1、AAV8-GFP，尾靜脈注射，肝脂肪代謝］

● Nature Communications. (IF 17.694). Zhong et.al. (2023). Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice. [中山大學(xué)附屬第六醫(yī)院 AAV8-TAK1；AAV8-Vec；AAV8-Adipoq-Cre AAV過表達(dá)載體肥胖代謝]

● Acta Pharmaceutica Sinica B.（IF=14.5）.Tang WZ，et.al.（2023）.Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice.［南方科技大學(xué)&南方科技大學(xué)第一附屬醫(yī)院 AAV-Rec2-CasRx-sgRNA-Kindlin-2 脂肪］

● Protein & Cell.（IF=15.328）.Maomao-Pu，et.al.（2023）.ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover .［浙江大學(xué)醫(yī)學(xué)院 AAV9-ORP8-WT 、AAV9-ORP8-T54A/S65A、AAV9-ORP8-LIRs-6A 、AAV9- ORP5 脂滴自噬］

● Cell Death and Differentiation?(IF=13.7)?.Liu C, et.al. (2024). Foxk1 promotes bone formation through inducing aerobic glycolysis.［深圳市人民醫(yī)院  AAV9-Osterix-Foxk1、AAV9-Osterix-GFP  骨形成］

● Cell Communication and Signaling (IF 8.2).Sun K, et.al. (2024). IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院 AAV9-shZBP1、AAV9-shGFP 骨關(guān)節(jié)炎］

● Free Radical Biology and Medicine.（IF=8.101）.Kai Sun，et.al.（2023）.JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院關(guān)節(jié)腔內(nèi)注射AAV9-NCOA4 & AAV9-GFP骨關(guān)節(jié)炎治療］

● Nature Metabolism (IF 18.9) Peng et.al. (2025). Cellular Feimin enhances exercise performance by suppressing muscle thermogenesis. [清華大學(xué)王一國 AAV9-cFeimin；AAV9-cFeimin 112/128T/A；AAV9-cFeimin 112/128T/D；AAV9-cFeimin 124/140R/D；AAV9-shcFeimin  肌肉產(chǎn)熱]

● Molecular Therapy (IF=12.4). Cataldi MP, et.al. (2023). Improved efficacy of FKRP AAV gene therapy by combination with ribitol treatment for LGMD2I.［Atrium Health卡羅來納醫(yī)療中心 AAV9-MCK-FKRP  肌營養(yǎng)不良］

● Science Advances（IF=13.6）. Jia M, et.al. (2023). ULK1-mediatedmetabolic reprogramming regulates Vps34 lipid kinase activity by itslactylation.［華東理工大學(xué) rAAV-Vps34WT、rAAV-Vps342KR、rAAV-Ctrl  骨骼肌穩(wěn)態(tài)］

● Skeletal Muscle (IF=4.9).Witcher PC, et.al. (2023). Expression of Myomaker and Myomerger in myofbers causes muscle pathology.［辛辛那提兒童醫(yī)院 AAV9-CMV-Myomerger 、AAV9-GFP  肌肉病理］

● Biomedicine & Pharmacotherapy（IF=7.5 ）.Wu Y, et.al. (2022). Endothelium-targeted delivery of PPARδ by adeno-associated virus serotype 1 ameliorates vascular injury induced by hindlimb ischemia in obese mice.［香港中文大學(xué) AAV1-ICAM2-Ppard 、AAV1-control  糖尿病血管病變］

● JCI Insight (IF=8.0).Kwong JQ, et.al. (2018). The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle.［辛辛那提兒童醫(yī)院 AAV9-Cre、 AAV9-GFP  骨骼肌代謝］

● Redox Biology，（IF 10.787）. Zhu Jian.（2023）. The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3 .［海軍軍醫(yī)大學(xué)第二附屬醫(yī)院（上海長征醫(yī)院），AAV-USP11 & AAV-Ctrl，椎間盤內(nèi)注射］

● Cell Reports.（IF=9.995）. Liu, et.al. (2022). Template-independent genome editing in the Pcdh15 av-3j mouse, a model of human DFNB23 nonsyndromic deafness.［清華大學(xué) AAV2/9-mCherry&AAV2/9-m-3j-gRNA1 遺傳性耳聾］

● Cell Reports Medicine (IF 14.3).Li CP, et.al. (2024). Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma.［中國科學(xué)院動(dòng)物研究所、北京同仁醫(yī)院 AAV2-CAG-PLAP、AAV2-CAG-CNTF 青光眼神經(jīng)退行性病變］

● Cell Death and Disease，（IF 9）.Li Y.（2023）. TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy.［南京醫(yī)科大學(xué)附屬無錫人民醫(yī)院，AAV8-shTGR5，AAV8-vector，玻璃體內(nèi)注射2μL，糖尿病視網(wǎng)膜病變］

● Antioxidants(IF7.675).ZhangF,et.al.(2023).Melatonin Alleviates Retinal Ischemia-Reperfusion Injury by Inhibiting p53–Mediated Ferroptosis.［中山大學(xué)中山眼科中心 AAV2-p53& AAV2-GFP 視網(wǎng)膜缺血再灌注］

● COMPUT STRUCT BIOTEC（IF 6.155）. Zhang J, et.al. (2023). PDGF-D-induced immunoproteasome activation and cell-cell interactions.［中山大學(xué)中山眼科中心&廣醫(yī)-廣州生物院 AAV-VMD2-PDGF-D&AAV-GFP 脈絡(luò)膜新生血管］

● International Journal of Biological Sciences. (IF=4.858). Wu, et.al. (2019). Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.［溫州醫(yī)科大學(xué)附屬第二醫(yī)院 AAV9-U6-shRNA (Prkaa1)-CMV-EGFP 隨意皮瓣］

● Cell Communication and Signaling (IF 8.9). Chen Y, et.al. (2025). Inhibition of tubular epithelial cells ferroptosis alleviates renal interstitial fibrosis by reducing lipid hydroperoxides and TGF-β/Smad signaling.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院 AAV9-mGPX4 、AAV9-vector 腎間質(zhì)纖維化］

● Free Radical Biology and Medicine (IF=7.1). Hu H, et.al. (2025). Dapagliflozin Attenuates Diabetes-Induced Podocyte Lipotoxicity via ERRα-Mediated Lipid Metabolism.［武漢大學(xué)人民醫(yī)院 AAV-nphs1-shACOX1、AAV-nphs1-null 糖尿病腎?。?/a>

● Molecular Therapy (IF 12.1).Song Z, et.al. (2024). The novel potential therapeutic target PSMP/MSMP promotes acute kidney injury via CCR2.［北大基礎(chǔ)醫(yī)學(xué)院、北大第一醫(yī)院 AAV9-hPSMP、AAV9-null 急性腎損傷］

● Metabolism Clinical and Experimental，（IF 9.8）. Zuo Fuwen.（2023）. CCDC92 deficiency ameliorates podocyte lipotoxicity in diabetic kidney disease.［山東大學(xué)基礎(chǔ)醫(yī)學(xué)院，AAV9-Nphs1-Ccdc92、AAV9-Nphs1-shAbca1，糖尿病腎病-腎實(shí)質(zhì)內(nèi)注射］

● Cell Death Discovery. (IF 7.0). Zhang et.al. (2023). Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis. [南京醫(yī)科大學(xué)第一附屬醫(yī)院 AAV慢病毒過表達(dá)載體 AAV9-RCAN1.4 LV-RCAN1.4、LV-YY1  腎臟]

● Life Sciences（IF=6.780）. Hu BC, et.al. (2023). Auto- and paracrine rewiring of NIX-mediated mitophagy by insulin-like growth factor-binding protein 7 in septic AKI escalates inflammation-coupling tubular damage.［浙江省人民醫(yī)院AAV9-KSP1.3-miR30-sh.NIX &AAV9-sh.scr 膿毒性AKI］

● Nature Communications?(IF=17.694). Yang Y, et.al. (2023). DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice.［南京醫(yī)科大學(xué)附屬兒童醫(yī)院AAV8-U6-gRNA-DNA-PKcs；AAV8-U6-gRNA 慢性腎臟?。?/a>

● Molecular Therapy. （IF=12.910）. Ouyang X, et.al. (2022). A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating AKT/mTOR-autophagy pathway. ［廣東人民醫(yī)院 AAV9-sh-circ-ZNF609 & AAV9-ZNF609-250 & AAV9-sh-NC 急性腎損傷］

● Cytokine.(IF=3.926). Xu H, Wang Z. (2022). MicroRNA-23a-3p ameliorates acute kidney injury by targeting FKBP5 and NF-κB signaling in sepsis.［江西省人民醫(yī)院 AAV2-miR-23a-3p 膿毒癥急性腎損傷］

● Molecular Therapy. (IF=12.910) . Sung-Ah Hong, et.al.（2021）. In vivo gene editing via homology-independent targeted integration for adrenoleukodystrophy treatment. [延世大學(xué)AAV9-HITI & AAV9-SaCas9-sgRNA & AAV9-EGFP 腎上腺腦白質(zhì)營養(yǎng)不良(ALD)]

● Acta Pharm Sin B. (IF=11.413). Jing X, et.al. (2021). Gene deficiency or pharmacological inhibition of PDCD4-mediated FGR signaling protects against acute kidney injury. ［山東大學(xué) rAAV9-Fgr-GFP & rAAV9-GFP 急性腎損傷］

● J Pharmacol Sci. (IF=3.337). Zhou J, et.al. (2021). Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499-5p/APC axis. ［南京中醫(yī)藥大學(xué)附屬醫(yī)院 AAV9-miR-499-5p & AAV9-APC 糖尿病腎?。?/a>

● EBIOMEDICINE. (IF=5.736). Liu, et.al. (2019). H19 promote calcium oxalate nephrocalcinosis-induced renal tubular epithelial cell injury via a ceRNA pathway.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院 AAV9-H19 腎鈣質(zhì)沉著癥］

● Science Translational Medicine. (IF=16.304). Wang, et.al. (2018). Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway.［南方醫(yī)科大學(xué) AAV9-MIR-GFP-lnc-TSI 腎纖維化］

● Allergy?(IF 12.4).Jia M, et.al. (2023). DEL-1, as an anti-neutrophil transepithelial migration molecule, inhibits airway neutrophilic inflammation in asthma.［南京醫(yī)科大學(xué)第一附屬醫(yī)院 AAV6-DEL-1 鼻吸 支氣管哮喘］

● Microbiology Spectrum（IF=9.043）.Zhang Z, et.al. (2023). Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via the miR-324-5p–CUEDC2 Axis.［浙江大學(xué)動(dòng)物醫(yī)學(xué)中心 AAV6-lnc-AROD & AAV6-NC 宿主先天防御］

● Cell Death & Disease. (IF=6.304). Zhang, et.al. (2019). circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.［上海市第一人民醫(yī)院 AAV6-circHIPK3 shRNA & scrambled shRNA 肺纖維化］

● Oncotarget. Tian, et.al. (2017). Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling.［華中科技大學(xué)同濟(jì)醫(yī)學(xué)院公共衛(wèi)生學(xué)院 AAV-Sirt6 特發(fā)性肺纖維化］

● Retrovirology. (IF=4.183). Wang, et.al. (2017). Genome modifcation of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection.［武漢大學(xué)基礎(chǔ)醫(yī)學(xué)院 AAV-SaCas9-CXCR4-gRNA HIV基因治療］

● AGING CELL（IF=8）. Chen M, et.al. (2025). Senescent Macrophages Promote Age-Related Revascularization Impairment by Increasing Antiangiogenic VEGF-A165B Expression.［湖南省婦幼保健院 AAV9-Lyz2-shVegf-a165b、AAV9-Scramble  年齡相關(guān)的血管再生障礙］

● Cell Metab. (IF=27.287). Loft Anne, et.al. (2022). A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis.［德國慕尼黑赫爾姆霍茨中心&烏爾姆大學(xué) AAV-LP1-Cre & AAV-LP1-Cremut 肝臟禁食與生酮反應(yīng)］

● EBioMedicine. (IF=8.143). Song Haoyu, Xu Tong, Feng Xiaofei, et.al. (2020). Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2.［南方醫(yī)科大學(xué)&暨南大學(xué)附屬珠海醫(yī)院 AAV2-Irg1-GFP & AAV2-Nrf2-GFP& AAV2-Keap1-GFP 腹主動(dòng)脈瘤AAA］

● EBioMedicine. (IF=5.736). Lian, et.al. (2019). Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway. ［北京大學(xué) AAV2-ADAM17-GFP & AAV2-GFP 主動(dòng)脈夾層AD］

● Circulation Research. (IF=14.467). Fu, et.al. (2016). Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Defciency Drives Atherosclerotic Calcifcation. ［北京大學(xué) AAV2-integrin β3 & AAV2-β-tail domain & AAV2-GFP 動(dòng)脈粥樣硬化AS］

● Leukemia (IF 11.4). Jiang J, et.al. (2023). Inserting EF1α-driven CD7-specific CAR at CD7 locus reduces fratricide and enhances tumor rejection.［浙大醫(yī)學(xué)院 AAV-CD7 CAR  CAR-T細(xì)胞療法］

● CLINICAL CANCER RESEARCH（IF=13.801）.Zhang Y, et.al. (2023). Allogeneic CAR T Cells Targeting DLL3 Are Efficacious and Safe in Preclinical Models of Small Cell Lung Cancer.［Allogene公司 AAV-IL7 & AAV-IL15 小細(xì)胞肺癌］

● Mol Ther. (IF=12.910). Duan Y, et.al. (2022). Balancing activation and costimulation of CAR tunes signaling dynamics and enhances therapeutic potency. ［浙江大學(xué)醫(yī)學(xué)院AAV-TRAC-1928z-WT & AAV-TRAC-1928z-1XX CAR-T細(xì)胞制備］

● Small Methods. (IF=15.367).Ruirui Jing，et.al.（2021）.Cas9-Cleavage Sequences in Size-Reduced Plasmids Enhance Nonviral Genome Targeting of CARs in Primary Human T Cells ［浙江大學(xué)AAV-TRAC-CAR-T ］

● Molecular Cell.(IF=17.970).Ling, et.al.(2021). Improving the efficiency of CRISPR-Cas12a-based genome editing with site-specific covalent Cas12a-crRNA conjugates.［北京大學(xué)AAV6-CD19 CAR CAR-T細(xì)胞制備］

● Molecular Therapy: Nucleic Acid（IF=10.183）.Iancu O, et.al. (2022). Multiplex HDR for Disease and Correction Modeling of SCID by CRISPR Genome Editing in Human HSPCs.［巴伊蘭大學(xué)  AAV6病毒產(chǎn)品 嚴(yán)重聯(lián)合免疫缺陷］

● Journal of Extracellular Vesicles. (IF 16). Huang et.al. (2023). Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis. [中山大學(xué)附屬第三醫(yī)院，AAV干擾載體、腹膜纖維化]

●CELL PROLIFERATION (IF 5.9).Zhang S, et.al. (2024). AAV-mediated gene therapy restores natural fertility and improves physical function in the Lhcgr-deficient mouse model of Leydig cell failure.［中山大學(xué) AAV8-CAG-Lhcgr、AAVDJ-CAG-Lhcgr 雄性不育］

●BMC Biology（IF=7.364）. Ying Z, et.al. (2022). CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72.［深圳大學(xué) HCR-KO HeLa細(xì)胞系 中心體組裝］

●Cellular & Molecular Immunology. (IF 22.096). Lv et.al. (2023). Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells. [吉林大學(xué)第一醫(yī)院表達(dá)ICOSL的細(xì)胞系 免疫]